Human cortical prostheses: lost in translation?
Human cortical prostheses: lost in translation?
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DOI：
10.3171/2009.4.focus0987
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发表时间：
2009-07
影响因子：
4.1
通讯作者：
Shenoy KV
中科院分区：
文献类型：
--
作者：
Ryu SI;Shenoy KV
大脑对假肢系统的直接控制是许多大众和科学新闻的主题。神经技术和神经科学已经发展到一定程度，在老鼠、猴子甚至人类身上已经有了皮质控制假肢的概念验证系统。然而，要实现让每个人都能使用这种技术的梦想仍然很遥远。幸运的是，如今公众和科学界都对实现这一目标抱有极大的兴趣，但只有当这种系统的功能益处超过风险时，这一目标才会实现。在这篇文章中，作者简要总结了该领域的技术现状，然后强调了许多将直接限制临床转化的问题，包括系统耐用性、系统性能和患者风险。尽管面临挑战，科学家和临床医生处于有利地位，拥有公众和财政支持，可以直接着手解决这些问题。现在的最终挑战是明确确定这些假肢系统是否会成为临床现实，还是永远无法实现。
Direct brain control of a prosthetic system is the subject of much popular and scientific news. Neural technology and science have advanced to the point that proof-of-concept systems exist for cortically-controlled prostheses in rats, monkeys, and even humans. However, realizing the dream of making such technology available to everyone is still far off. Fortunately today there is great public and scientific interest in making this happen, but it will only occur when the functional benefits of such systems outweigh the risks. In this article, the authors briefly summarize the state of the art and then highlight many issues that will directly limit clinical translation, including system durability, system performance, and patient risk. Despite the challenges, scientists and clinicians are in the desirable position of having both public and fiscal support to begin addressing these issues directly. The ultimate challenge now is to determine definitively whether these prosthetic systems will become clinical reality or forever unrealized.