Multilevel assessment of the neurobiological threat system in depressed adolescents: interplay between the limbic system and hypothalamic-pituitary-adrenal axis.
Multilevel assessment of the neurobiological threat system in depressed adolescents: interplay between the limbic system and hypothalamic-pituitary-adrenal axis.
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DOI：
10.1017/s0954579414001059
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发表时间：
2014-11
影响因子：
3.3
通讯作者：
Cullen KR
中科院分区：
文献类型：
--
作者：
Klimes-Dougan B;Eberly LE;Westlund Schreiner M;Kurkiewicz P;Houri A;Schlesinger A;Thomas KM;Mueller BA;Lim KO;Cullen KR
综合的，多层次的方法调查相关的威胁检测神经生物学系统的承诺，以促进理解的病理生理学的重性抑郁症（MDD）。在这项研究中，我们考虑了MDD青少年和健康对照（HC）的关键神经元和激素系统。本研究的目的是确定组的差异，并检查神经元和激素系统的关联。入组了12-19岁MDD和HC青少年（N = 79）。关键的大脑测量包括杏仁核体积和杏仁核激活的情绪面孔观察任务。关键的激素测量包括在社会压力任务和大脑扫描期间的皮质醇水平。MDD和HC青少年在杏仁核功能和皮质醇水平模式上存在组间差异。杏仁核对情绪刺激的反应与皮质醇反应呈正相关。此外，杏仁核体积与皮质醇反应相关，但抑郁与健康青少年的模式不同，最明显的是未服药的MDD青少年。研究结果强调了使用多层次评估策略的价值，以提高对青少年MDD病理生理学的理解，特别是关于密切相关的生物威胁系统如何在经历重大发展转变的同时共同发挥作用。
Integrative, multilevel approaches investigating neurobiological systems relevant to threat detection promise to advance understanding of the pathophysiology of major depressive disorder (MDD). In this study we considered key neuronal and hormonal systems in adolescents with MDD and healthy controls (HC). The goals of this study were to identify group differences and to examine the association of neuronal and hormonal systems. MDD and HC adolescents (N = 79) aged 12–19 years were enrolled. Key brain measures included amygdala volume and amygdala activation to an emotion face-viewing task. Key hormone measures included cortisol levels during a social stress task and during the brain scan. MDD and HC adolescents showed group differences on amygdala functioning and patterns of cortisol levels. Amygdala activation in response to emotional stimuli was positively associated with cortisol responses. In addition, amygdala volume was correlated with cortisol responses, but the pattern differed in depressed versus healthy adolescents, most notably for unmedicated MDD adolescents. The findings highlight the value of using multilevel assessment strategies to enhance understanding of pathophysiology of adolescent MDD, particularly regarding how closely related biological threat systems function together while undergoing significant developmental shifts.