Metastasizing splenic littoral cell hemangioendothelioma
Metastasizing splenic littoral cell hemangioendothelioma
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DOI：
10.1097/00000478-200608000-00016
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发表时间：
2006-08-01
影响因子：
5.6
通讯作者：
Arber, Daniel A.
中科院分区：
文献类型：
--
作者：
Fernandez, Susan;Cook, George W.;Arber, Daniel A.
沿岸的细胞血管瘤是一种独特的脾脏肿瘤，通常被认为是良性的。我们报告一个低级别的沿岸的细胞脾肿瘤，在脾切除术后4年转移到肝脏和腹膜后。虽然脾脏病变表现出典型的沿岸的细胞血管瘤的形态，但它也包含有不寻常的细胞学上平淡的实性巢，细胞质透明的饱满细胞。肝脏仅被具有类似透明细胞特征的细胞弥漫性浸润。脾脏和肝脏病变表现出相同的免疫表型，典型的沿岸的细胞血管瘤，表达CD 31，CD 68，CD 21，和CD 163，虽然CD8和CD 34阴性。一个单一的先前描述的沿岸的细胞血管内皮瘤表现为核变性和坏死，这是第一个病例报告的脾沿岸的细胞血管内皮瘤与一个完全温和的组织学外观。这个病例提示在沿岸的细胞血管瘤中出现透明细胞的实性区域可能是这些肿瘤低度恶性潜能的市场。
Littoral cell angioma is a unique splenic tumor that is generally considered to be benign. We present a case of a low-grade littoral cell splenic tumor that metastasized to the liver and retroperitoneum 4 years after splenectomy. Although the splenic lesion showed the typical morphology of a littoral cell angioma, it also contained areas with unusual solid nests of cytologically bland, plump cells with clear cytoplasm. The liver was diffusely infiltrated exclusively by cells with similar clear cell features. Both splenic and liver lesions demonstrated identical immunophenotypes, typical of littoral cell angioma, expressing CD31, CD68, CD21, and CD163, although negative for CD8 and CD34. A, single prior description of a littoral cell hemangioendothelioma showed nuclear atypia and necrosis, and this is the first case report of a splenic littoral cell hemangioendothelioma with a completely bland histologic appearance. This case suggests that the presence of solid areas of clear cells in a littoral cell angioma may be a market of low-grade malignant potential in these tumors.