Predictors of serum ferritin and serum soluble transferrin receptor in newborns and their associations with iron status during the first 2 y of life
Predictors of serum ferritin and serum soluble transferrin receptor in newborns and their associations with iron status during the first 2 y of life
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DOI：
10.1093/ajcn/86.1.64
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发表时间：
2007-07-01
影响因子：
7.1
通讯作者：
Borch-Iohnsen, Berit
中科院分区：
文献类型：
--
作者：
Hay, Gry;Refsum, Helga;Borch-Iohnsen, Berit
背景：出生时充足的铁状态可预防儿童早期铁缺乏症。目的：我们的目的是确定健康新生儿血清铁蛋白 (SF) 和血清可溶性转铁蛋白受体 (sTfR) 的预测因子，并将这些铁指数与生命前 2 年内的铁状态联系起来。设计：使用双变量相关性和线性回归，我们将妊娠期的各种因素与 SF (n = 363) 和 sTfR (n = 350) 联系起来。健康的足月婴儿。将脐带 SF 和 sTfR 的测量值与 6、12 和 24 个月时的 SF 和 sTfR 测量值进行比较。所有 4 次测量分别适用于 191 名和 169 名婴儿的 SF 和 sTfR。 结果：几何平均（和 95% CI）脐带 SF 和 sTfR 测量值分别为 159（148、171）μg/L 和 7.3（7.0、7.6）mg/L。脊髓 SF 与 sTfR 相关（rho = -0.21，P < 0.001）。在回归分析中，脐带 SF 与怀孕期间吸烟和使用铁补充剂相关（部分 r = -0.12 和 0.16；两者 P < 0.05）。脐带 sTfR 与妊娠早期 BMI、胎龄和男性性别相关（部分 r 分别 = 0.30、0.24 和 0.19；全部 P < 0.01）。脊髓 SF 与 6、12 和 24 个月时的 SF 相关（rho 分别 = 0.45、0.31 和 0.16；全部 P < 0.05）。 6 个月时，17 名 SF < 15 mu g/L 的婴儿中有 16 名是男孩。结论：怀孕期间戒烟和充分预防铁剂可能会改善婴儿期的铁状况。脐带 SF 是生命前 2 年内铁状态的预测因子。男孩在婴儿期早期特别容易出现铁含量低的风险。
Background: Adequate iron status at birth may prevent iron deficiency in early childhood.Objectives: We aimed to identify predictors of serum ferritin (SF) and serum soluble transferrin receptor (sTfR) in healthy newborns and to relate these iron indexes to iron status in the first 2 y of life.Design: Using bivariate correlations and linear regression, we related various factors in pregnancy to SF (n = 363) and sTfR (n = 350) in healthy, term infants. Measurements of cord SF and sTfR were compared with those of SF and sTfR at 6, 12, and 24 mo. All 4 measurements were available for 191 and 169 infants for SF and sTfR, respectively.Results: Geometric mean (and 95% CI) cord SF and sTfR measurements were 159 (148, 171) mu g/L and 7.3 (7.0, 7.6) mg/L, respectively. Cord SF correlated with sTfR (rho = -0.21, P < 0.001). In regression analysis, cord SF correlated with smoking and the use of iron supplements during pregnancy (partial r = -0.12 and 0.16; P < 0.05 for both). Cord sTfR was associated with first trimester BMI, gestational age, and male sex (partial r = 0.30, 0.24, and 0.19, respectively; P < 0.01 for all). Cord SF correlated with SF at 6, 12, and 24 mo (rho = 0.45, 0.31, and 0.16 respectively; P < 0.05 for all). At age 6 mo, 16 of 17 infants with SF < 15 mu g/L were boys.Conclusions: Cessation of smoking and adequate iron prophylaxis during pregnancy may improve iron status in infancy. Cord SF is a predictor of iron status in the first 2 y of life. Boys are at particular risk of low iron status in early infancy.