Anteriorization of neural fate by inhibitor of β-catenin and T cell factor (ICAT), a negative regulator of Wnt signaling
Anteriorization of neural fate by inhibitor of β-catenin and T cell factor (ICAT), a negative regulator of Wnt signaling
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DOI：
10.1073/pnas.0401733101
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发表时间：
2004-05-25
影响因子：
11.1
通讯作者：
Akiyama, T
中科院分区：
文献类型：
--
作者：
Satoh, K;Kasai, M;Akiyama, T
β-连环蛋白和T细胞因子抑制剂（Inhibitor of beta-catenin and T cell factor，ICAT）通过干扰β-连环蛋白和T细胞因子之间的相互作用抑制Wnt信号传导。在这里，我们发现ICAT（-/-）胚胎表现出前脑和颅面骨畸形，缺乏肾脏。胚胎干细胞的神经元分化的分析表明，Wnt 3a重定向神经祖细胞的命运，以后部字符，而ICAT诱导前脑细胞通过抑制Wnt信号。此外，ICAT（-/-）胚胎干细胞被发现分化成神经元细胞具有后部特征。这些结果表明，ICAT通过抑制Wnt信号的后向化活性，在神经细胞的前向化中起重要作用。
Inhibitor of beta-catenin and T cell factor (ICAT) inhibits Wnt signaling by interfering with the interaction between beta-catenin and T cell factor. Here we show that ICAT(-/-) embryos exhibit malformation of the forebrain and craniofacial bones and lack the kidney. Analysis of the neuronal differentiation of embryonic stem cells revealed that Wnt3a redirects the fate of neural progenitors to a posterior character, whereas ICAT induces forebrain cells by inhibiting Wnt signaling. Furthermore, ICAT(-/-) embryonic stem cells were found to differentiate into neuronal cells possessing a posterior character. These results suggest that ICAT plays an important role in the anteriorization of neural cells by inhibiting the posteriorizing activity of Wnt signaling.