The role of p53-induced apoptosis in cerebral ischemia:: effects of the p53 inhibitor pifithrin α
The role of p53-induced apoptosis in cerebral ischemia:: effects of the p53 inhibitor pifithrin α
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DOI：
10.1016/j.expneurol.2004.01.030
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发表时间：
2004-06-01
影响因子：
5.3
通讯作者：
Ovadia, H
中科院分区：
文献类型：
--
作者：
Leker, RR;Aharonowiz, M;Ovadia, H
临床上没有可用于治疗缺血性中风的神经保护化合物。研究了pifithrin a（一种转录因子p53的新型特异性抑制剂）在局灶性可逆性脑缺血后1-6小时施用的潜在有益作用。测量组织学、运动和行为结果的研究表明，pifithrin a 治疗的动物有显着改善。 Pifithrin a 通过抑制 p53 与其 DNA 位点的结合来减少缺血脑中凋亡细胞的数量，因为它减少了 p53 相关基因 p21 (WAF) 的表达，而不改变 p53 蛋白本身的量。 (C) 2004 Elsevier Inc. 保留所有权利。
No neuroprotective compounds are clinically available for the treatment of ischemic stroke. The potential salutary effect of pifithrin a, a novel-specific inhibitor of the transcription factor p53, administered 1-6 h following focal reversible cerebral ischemia, was investigated. Studies measuring histological, motor, and behavioral outcomes showed significant improvements in pifithrin a-treated animals. Pifithrin a reduced the number of apoptotic cells in the ischemic brain by inhibiting the binding of p53 to its DNA sites as it reduced the expression of the p53-related gene p21(WAF) without changing the amount of p53 protein itself. (C) 2004 Elsevier Inc. All rights reserved.