Synthesis of Bisindole Alkaloids from the Apocynaceae Which Contain a Macroline or Sarpagine Unit: A Review.
Synthesis of Bisindole Alkaloids from the Apocynaceae Which Contain a Macroline or Sarpagine Unit: A Review.
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来自含有大环内林或肉毒杆菌单元的双旋核生物碱的合成：综述。
DOI：
10.3390/molecules21111525
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发表时间：
2016-11-14
期刊：
影响因子：
--
通讯作者：
Cook JM
中科院分区：
文献类型：
--
作者：
Rahman MT;Tiruveedhula VV;Cook JM
双吲哚类天然产物是由两个吲哚生物碱单体组成的。双吲哚在其生物活性方面比其相应的单体单元更有效。此外，双吲哚的合成远比单体吲哚生物碱的合成更具挑战性。本文综述了夹竹桃科灯心草属植物双吲哚生物碱的对映体专一性全合成和部分合成。单体单元属于sarpagine、ajeline、macroline、vobasine和pleiocarpamine系列。最新的讨论，他们的分离，表征，生物活性，以及他们的部分和全部合成的合成和生物合成策略的手段。
Bisindole natural products consist of two monomeric indole alkaloid units as their obligate constituents. Bisindoles are more potent with respect to their biological activity than their corresponding monomeric units. In addition, the synthesis of bisindoles are far more challenging than the synthesis of monomeric indole alkaloids. Herein is reviewed the enantiospecific total and partial synthesis of bisindole alkaloids isolated primarily from the Alstonia genus of the Apocynaceae family. The monomeric units belong to the sarpagine, ajmaline, macroline, vobasine, and pleiocarpamine series. An up-to-date discussion of their isolation, characterization, biological activity as well as approaches to their partial and total synthesis by means of both synthetic and biosynthetic strategies are presented.