Hepatitis E Virus Immunopathogenesis.
Hepatitis E Virus Immunopathogenesis.
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戊型肝炎病毒免疫发病机制。
DOI：
10.3390/pathogens10091180
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发表时间：
2021-09-13
期刊：
影响因子：
--
通讯作者：
Kenney SP
中科院分区：
文献类型：
--
作者：
Yadav KK;Kenney SP
戊型肝炎病毒是一种重要的新兴病原体，对孕妇和免疫功能低下的患者产生致命影响。从 1983 年开始，它被描述为通过粪口途径传播的急性肝炎的原因。然而，在过去的几十年里，HEV 的人畜共患和输血传播的报道不断增多，引发了对 HEV 发病机制的详细研究。戊型肝炎病毒对孕妇特别是在妊娠晚期具有高毒力并导致孕产妇和胎儿死亡的原因仍不清楚。人们对各种宿主因素（免疫、营养、激素）和病毒因素进行了研究，以确定帮助 HEV 对妊娠和免疫功能低下患者产生毒力的关键决定因素。同样，慢性肝炎尤其常见于实体器官移植患者，导致致命的情况。这篇综述描述了一般人群、孕妇和免疫功能低下人群中 HEV 感染免疫病理生理学的最新进展，并进一步阐明了用于了解 HEV 发病机制的体外和体内模型。
Hepatitis E virus is an important emerging pathogen producing a lethal impact on the pregnant population and immunocompromised patients. Starting in 1983, it has been described as the cause for acute hepatitis transmitted via the fecal–oral route. However, zoonotic and blood transfusion transmission of HEV have been reported in the past few decades, leading to the detailed research of HEV pathogenesis. The reason behind HEV being highly virulent to the pregnant population particularly during the third trimester, leading to maternal and fetal death, remains unknown. Various host factors (immunological, nutritional, hormonal) and viral factors have been studied to define the key determinants assisting HEV to be virulent in pregnant and immunocompromised patients. Similarly, chronic hepatitis is seen particularly in solid organ transplant patients, resulting in fatal conditions. This review describes recent advances in the immunopathophysiology of HEV infections in general, pregnant, and immunocompromised populations, and further elucidates the in vitro and in vivo models utilized to understand HEV pathogenesis.
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DOI：
10.1073/pnas.1705446114
发表时间：
2017-07-03
影响因子：
11.1
作者：
Cao, Dianjun;Cao, Qian M.;Meng, Xiang-Jin
通讯作者：
Meng, Xiang-Jin
影响因子：
2.5
作者：
Drave, S. A.;Debing, Y.;Steinmann, E.
通讯作者：
Steinmann, E.
影响因子：
6.7
作者：
Debes, Jose D.;Pas, Suzan D.;Boonstra, Andre
通讯作者：
Boonstra, Andre
影响因子：
6.7
作者：
El Costa H;Gouilly J;Abravanel F;Bahraoui E;Peron JM;Kamar N;Jabrane-Ferrat N;Izopet J
通讯作者：
Izopet J
影响因子：
4.6
作者：
Ankavay, Maliki;Montpellier, Claire;Cocquerel, Laurence
通讯作者：
Cocquerel, Laurence