Recommendations for Laboratory Containment and Management of Gene Drive Systems in Arthropods.
Recommendations for Laboratory Containment and Management of Gene Drive Systems in Arthropods.
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DOI：
10.1089/vbz.2017.2121
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发表时间：
2018-01
期刊：
影响因子：
--
通讯作者：
Adelman ZN
中科院分区：
文献类型：
--
作者：
Benedict MQ;Burt A;Capurro ML;De Barro P;Handler AM;Hayes KR;Marshall JM;Tabachnick WJ;Adelman ZN
用于创造驱动转基因和其他侵入性遗传因素的多功能分子工具提出了监管、伦理和环境方面的挑战，应该解决这些挑战，以确保它们的安全使用。在这篇文章中，我们讨论了驱动转基因和侵入性遗传因素，这些遗传因素在引入种群中一小部分个体后可能会传播。入侵性遗传因素增加自然种群数量的潜力提出了挑战，需要额外的安全措施，而不是以前关于节肢动物意外释放的建议。除了提供物理控制外，侵入性遗传因素还需要更多地关注菌株管理，包括它们的分布和身份确认。在这项研究中，我们将重点放在含有这些因素的昆虫上，并向创造这些因素的研究人员、负责确保安全的机构生物安全委员会、提供支持的资助机构、处理这些材料的昆虫管理人员（负责控制）以及将从这些设施接收昆虫（无论是否为转基因昆虫）的其他人提出建议。我们给出了改造蚊子以控制蚊媒疾病的具体例子，但类似的考虑也适用于对人类健康、环境和农业重要的其他节肢动物。
Versatile molecular tools for creating driving transgenes and other invasive genetic factors present regulatory, ethical, and environmental challenges that should be addressed to ensure their safe use. In this article, we discuss driving transgenes and invasive genetic factors that can potentially spread after their introduction into a small proportion of individuals in a population. The potential of invasive genetic factors to increase their number in natural populations presents challenges that require additional safety measures not provided by previous recommendations regarding accidental release of arthropods. In addition to providing physical containment, invasive genetic factors require greater attention to strain management, including their distribution and identity confirmation. In this study, we focus on insects containing such factors with recommendations for investigators who are creating them, institutional biosafety committees charged with ensuring safety, funding agencies providing support, those managing insectaries handling these materials who are responsible for containment, and other persons who will be receiving insects—transgenic or not—from these facilities. We give specific examples of efforts to modify mosquitoes for mosquito-borne disease control, but similar considerations are relevant to other arthropods that are important to human health, the environment, and agriculture.
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DOI：
10.1126/science.aaa5945
发表时间：
2015-04-24
期刊：
Science (New York, N.Y.)
影响因子：
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作者：
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通讯作者：
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影响因子：
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影响因子：
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影响因子：
15.8
作者：
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通讯作者：
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DOI：
10.1073/pnas.1611064114
发表时间：
2017-01-10
影响因子：
11.1
作者：
Eckhoff, Philip A.;Wenger, Edward A.;Burt, Austin
通讯作者：
Burt, Austin