EFFECTS OF CIGARETTE-SMOKING ON MOTOR FUNCTIONS IN PATIENTS WITH MULTIPLE-SCLEROSIS
EFFECTS OF CIGARETTE-SMOKING ON MOTOR FUNCTIONS IN PATIENTS WITH MULTIPLE-SCLEROSIS
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DOI：
10.1001/archneur.1992.00530360041015
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发表时间：
1992-12-01
影响因子：
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通讯作者：
DEDECKER, C
中科院分区：
文献类型：
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作者：
EMRE, M;DEDECKER, C
对21例多发性硬化症患者和11例健康体检者进行了吸烟对运动功能的急性影响。上肢运动功能通过简单的测试电池进行评估。21名患者中有16名在吸烟后立即出现一过性的运动功能恶化，持续了10分钟。所有21名患者的运动能力评分平均下降了14%。在不吸烟的情况下进行同样的测试，14名患者中只有3名病情恶化，而这组患者的平均改善幅度为8%。控制组随着时间的推移，无论是在吸烟还是在模拟实验中，都表现出了稳步的改善。我们得出结论，尼古丁会导致多发性硬化症患者运动功能的一过性恶化，这可能是由于尼古丁对中枢神经系统或植物血管功能的影响。
The acute effects of cigarette smoking on motor functions were examined in 21 patients with multiple sclerosis and 11 healthy control subjects. The motor function in the upper extremities was assessed by a simple test battery. Sixteen of 21 patients had a transient deterioration of their motor function immediately after smoking, lasting for 10 minutes. The mean decrease in motor performance score for all 21 patients was 14%. With the same tests performed without smoking only three of 14 patients had a deterioration and the group had a mean 8% improvement. The control group showed a steady improvement over time, both in smoking and in simulation experiments. We conclude that nicotine causes a transient worsening of motor functions in patients with multiple sclerosis, which can be due to its effects on the central nervous system or vegetative-vascular functions.