Spatiotemporal Coordination of Slow-Wave Ongoing Activity across Auditory Cortical Areas
Spatiotemporal Coordination of Slow-Wave Ongoing Activity across Auditory Cortical Areas
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DOI：
10.1523/jneurosci.5079-12.2013
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发表时间：
2013-02-20
影响因子：
5.3
通讯作者：
Norena, Arnaud J.
中科院分区：
文献类型：
--
作者：
Farley, Brandon J.;Norena, Arnaud J.
自然声刺激包含缓慢的时间波动，自下而上和自上而下的因素对正在进行的慢波活动的调制在听觉皮层处理中起着至关重要的作用。然而，在听觉皮层模态的内在慢波活动的时空模式是未知的。在麻醉的豚鼠体内使用电压敏感染料成像，我们测量了几个核心和带听觉皮层区域对声刺激的频谱调谐，然后记录了这个定义的网络中的自发活动。我们发现，在自发慢波（δ-θ带）活动的相位相干性是最高的核心和带区域之间的区域，有类似的频率调谐，即使他们是遥远的。此外，具有高相位相干性的芯和带区域被相移。有趣的是，在自发活动中观察到的相移与诱发活动的潜伏期差异有关。我们的研究结果表明，这种慢波活动的内在来源的电路支持协调的变化之间的兴奋性功能匹配，但分布区域的听觉皮层网络。
Natural acoustic stimuli contain slow temporal fluctuations, and the modulation of ongoing slow-wave activity by bottom-up and top-down factors plays essential roles in auditory cortical processing. However, the spatiotemporal pattern of intrinsic slow-wave activity across the auditory cortical modality is unknown. Using in vivo voltage-sensitive dye imaging in anesthetized guinea pigs, we measured spectral tuning to acoustic stimuli across several core and belt auditory cortical areas, and then recorded spontaneous activity across this defined network. We found that phase coherence in spontaneous slow-wave (delta-theta band) activity was highest between regions of core and belt areas that had similar frequency tuning, even if they were distant. Further, core and belt regions with high phase coherence were phase shifted. Interestingly, phase shifts observed during spontaneous activity paralleled latency differences for evoked activity. Our findings suggest that the circuits underlying this intrinsic source of slow-wave activity support coordinated changes in excitability between functionally matched but distributed regions of the auditory cortical network.