The effect of alternate-day caloric restriction on the metabolic consequences of 8 days of bed rest in healthy lean men: a randomized trial
The effect of alternate-day caloric restriction on the metabolic consequences of 8 days of bed rest in healthy lean men: a randomized trial
复制标题
DOI：
10.1152/japplphysiol.00846.2016
复制
发表时间：
2017-02-01
影响因子：
3.3
通讯作者：
Krogh-Madsen, Rikke
中科院分区：
文献类型：
--
作者：
Harder-Lauridsen, Nina Majlund;Nielsen, Signe Tellerup;Krogh-Madsen, Rikke
体力活动和隔日禁食/热量限制都可以通过重叠机制改善代谢综合征的各个方面，例如胰岛素抵抗、内脏脂肪堆积和认知障碍。本研究的目的是检验这样的假设：在连续 8 天卧床休息后，隔日热量限制 (ADCR) 与整体能量平衡除了可以改善认知功能之外，还可以减少胰岛素抵抗和内脏脂肪的积累。健康、瘦弱的男性 (n = 20) 被随机分为 1) 卧床休息 8 天，每日三餐等能量膳食（对照组，n = 10）； 2）卧床休息8天，每隔一天达到总能量需求的25%，每隔一天达到总能量需求的175%（ADCR组）。卧床休息前后进行口服葡萄糖耐量测试、双能X射线吸收测定（DXA）扫描、腹部和大脑磁共振成像、最大摄氧量和认知功能测试。此外，在8天的卧床休息期间，通过连续血糖监测系统评估每日空腹血样和24小时血糖曲线。卧床休息会导致胰岛素抵抗、内脏脂肪堆积和情绪恶化。 ADCR 对这些负面健康结果没有产生积极影响。与对照组相比，ADCR与禁食日的血糖控制改善和稳定以及暴饮暴食日的较高血糖波动和胰岛素抵抗指数相关。与我们的假设相反，ADCR 并没有通过总体能量平衡来抵消 8 天卧床引起的代谢损伤。新的和值得注意的隔日热量限制而不减少总体能量并不能改善瘦男性因卧床 8 天引起的代谢损伤。
Physical activity and alternate-day fasting/caloric restriction may both ameliorate aspects of the metabolic syndrome, such as insulin resistance, visceral fat mass accumulation, and cognitive impairment by overlapping mechanisms. The purpose of this study was to test the hypothesis that alternate-day caloric restriction (ADCR) with overall energy balance would reduce insulin resistance and accumulation of visceral fat, in addition to improving cognitive functions, after 8 consecutive days in bed. Healthy, lean men (n = 20) were randomized to 1) 8 days of bed rest with three daily isoenergetic meals (control group, n = 10); and 2) 8 days of bed rest with 25% of total energy requirements every other day and 175% of total energy requirements every other day (ADCR group). Oral glucose tolerance testing, dual-energy X-ray absorptiometry (DXA) scans, magnetic resonance imaging of the abdomen and brain, VO2max, and tests for cognitive function were performed before and after bed rest. In addition, daily fasting blood samples and 24-h glucose profiles by continuous glucose monitoring system were assessed during the 8 days of bed rest period. Bed rest induced insulin resistance, visceral fat accumulation, and worsening of mood. No positive effects emerged from ADCR on these negative health outcomes. Compared with the control group, ADCR was associated with improved and steadier glycemic control on fasting days and higher glycemic fluctuation and indexes of insulin resistance on overeating days. In contrast to our hypothesis, the metabolic impairment induced by 8 days of bed rest was not counteracted by ADCR with overall energy balance.NEW & NOTEWORTHY Alternate-day caloric restriction without overall energy reduction does not ameliorate the metabolic impairment induced in lean men by 8 days of bed rest.