The Restorative Effects of Eucommia ulmoides Oliver Leaf Extract on Vascular Function in Spontaneously Hypertensive Rats.
The Restorative Effects of Eucommia ulmoides Oliver Leaf Extract on Vascular Function in Spontaneously Hypertensive Rats.
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DOI：
10.3390/molecules201219826
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发表时间：
2015-12-09
期刊：
影响因子：
--
通讯作者：
Nakamura K
中科院分区：
文献类型：
--
作者：
Hosoo S;Koyama M;Kato M;Hirata T;Yamaguchi Y;Yamasaki H;Wada A;Wada K;Nishibe S;Nakamura K
杜仲叶叶是一种传统的中国抗高血压和抗糖尿病药物。我们研究了长期给予杜仲叶提取物（ELE）对自发性高血压大鼠（SHR）动脉功能和形态的影响。ELE通过正常饮食随意口服给药6周龄雄性SHR，浓度为5%，持续7周。测定乙酰胆碱（ACh）诱导的内皮依赖性舒张、硝普钠（SNP）诱导的内皮非依赖性舒张、血浆一氧化氮（NO）水平和中膜厚度。ELE显着改善乙酰胆碱诱导的主动脉内皮依赖性舒张，但不影响SNP诱导的内皮非依赖性舒张的SHR，相比，接受正常饮食的动物。血浆NO水平和中膜厚度显着增加和减少，分别在ELE治疗的SHR。因此，长期ELE给药可通过增加血浆NO水平和生物利用度，并通过防止SHR主动脉中的血管肥大来有效地改善血管功能。
Eucommia ulmoides Oliv. leaf is a traditional Chinese antihypertensive and antidiabetic medicine. We examined the effects of chronic Eucommia leaf extract (ELE) administration on artery function and morphology in spontaneously hypertensive rats (SHRs). ELE was orally administered via normal diet ad libitum to six-week-old male SHRs at a concentration of 5% for seven weeks. Acetylcholine (ACh)-induced endothelium-dependent relaxation, sodium nitroprusside (SNP)-induced endothelium-independent relaxation, plasma nitric oxide (NO) levels, and media thickness were assessed. ELE significantly improved ACh-induced aortic endothelium-dependent relaxation but did not affect SNP-induced endothelium-independent relaxation in the SHRs, as compared to the animals receiving normal diet. Plasma NO levels and media thickness were significantly increased and decreased, respectively, in the ELE-treated SHRs. Therefore, long-term ELE administration may effectively improve vascular function by increasing plasma NO levels and bioavailability, and by preventing vascular hypertrophy in the SHR aorta.
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影响因子：
2.5
作者：
Fujikawa, Takahiko;Hirata, Tetsuya;Hosoo, Shingo;Nakajima, Kenji;Wada, Atsunori;Yurugi, Yutaka;Soya, Hideaki;Matsui, Takashi;Yamaguchi, Akihiko;Ogata, Masato;Nishibe, Sansei
通讯作者：
Nishibe, Sansei
影响因子：
6.7
作者：
Antonopoulos, Alexios S.;Margaritis, Marios;Antoniades, Charalambos
通讯作者：
Antoniades, Charalambos
DOI：
10.1152/ajpheart.01240.2004
发表时间：
2005-08-01
影响因子：
4.8
作者：
Santos, AC;Alves, MJNN;Negrao, CE
通讯作者：
Negrao, CE
影响因子：
4.9
作者：
Sánchez, M;Galisteo, M;Duarte, J
通讯作者：
Duarte, J
DOI：
10.1152/ajpheart.00292.2006
发表时间：
2006-09-01
影响因子：
4.8
作者：
Feletou, Michel;Vanhoutte, Paul M.
通讯作者：
Vanhoutte, Paul M.