ORIGINS OF BLOOD ACETATE IN RAT
ORIGINS OF BLOOD ACETATE IN RAT
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DOI：
10.1042/bj1660539
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发表时间：
1977-01-01
影响因子：
4.1
通讯作者：
WILLIAMSON, DH
中科院分区：
文献类型：
--
作者：
BUCKLEY, BM;WILLIAMSON, DH
描述了一种新的测定生物材料中醋酸酯的酶循环试验。用这种方法测定了不同年龄和营养状态的大鼠血液和肝脏样品中的醋酸盐浓度。研究了肠、肝和身体其他部位对维持循环中醋酸盐浓度的作用。有证据表明，肠道菌群是喂养成年大鼠血液中醋酸盐的主要来源，尽管内源性醋酸盐的产生在其他情况下也有重要意义。链脲佐菌素糖尿病大鼠血醋酸盐浓度升高。
A novel enzymic cycling assay for the determination of acetate in biological material is described. Measurements of the acetate concentration in blood and liver samples from rats of various ages and nutritional states with this assay are reported. The contribution of the intestine, the liver and the rest of the body to maintaining the concentration of acetate in the circulation is examined. Evidence is presented that the gut flora constitute the main source of acetate in blood of fed adult rats, though endogenous production of acetate is of significance in other situations. The streptozotocin-diabetic rat has an elevated blood acetate concentration.