Interpretation of plasma protein measurements in end-stage renal disease.
Interpretation of plasma protein measurements in end-stage renal disease.
复制标题
终末期肾病血浆蛋白测量的解释。
DOI：
10.1159/000014459
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发表时间：
2000
影响因子：
3
通讯作者：
Kaysen,GA
中科院分区：
文献类型：
--
作者：
Kaysen,GA
终末期肾病的特征是异常的死亡率。大部分死亡率是心血管疾病的结果[1]。血清蛋白的测定可用于预测死亡率[2]。重要的预测因子是低白蛋白血症[2，3]、低胆固醇血症[2]和急性期蛋白水平[4，5]或调节其产生的细胞因子[6]。如果假设临床结果可以通过改变引起血浆蛋白组成的这些预测性变化的过程来改变，则必须首先了解负责改变血浆蛋白组成的过程，以改善临床结果。由于这些蛋白质中的每一种的血浆水平由各种输入控制，因此血浆水平的解释可能是复杂的。
End-stage renal disease is characterized by an exceptional mortality rate. Much of this mortality is a result of cardiovascular disease [1]. Measurement of serum proteins has been of use in predicting mortality [2]. Important predictors have been hypoalbuminemia [2, 3], hypocholesterolemia [2] and the levels of acute-phase proteins [4, 5] or the cytokines that regulate their production [6]. If one assumes that clinical outcome can be changed by altering the processes that cause these predictive changes in plasma protein composition, then one must first understand the processes responsible for changed plasma protein composition in order to improve clinical outcome. Since the plasma levels of each of these proteins are controlled by a variety of inputs, interpretation of plasma levels may be complex.