SECRETION AND LOCALIZED TRANSCRIPTION SUGGEST A ROLE IN POSITIONAL SIGNALING FOR PRODUCTS OF THE SEGMENTATION GENE HEDGEHOG
SECRETION AND LOCALIZED TRANSCRIPTION SUGGEST A ROLE IN POSITIONAL SIGNALING FOR PRODUCTS OF THE SEGMENTATION GENE HEDGEHOG
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DOI：
10.1016/0092-8674(92)90264-d
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发表时间：
1992-10-02
期刊：
影响因子：
64.5
通讯作者：
BEACHY, PA
中科院分区：
文献类型：
--
作者：
LEE, JJ;VONKESSLER, DP;BEACHY, PA
在果蝇类节段边界两侧相邻的细胞条纹中表达片段极性基因Engraated和Wingless。每一个基因都是维持另一个基因表达所必需的；两个基因的持续表达还需要几个其他的片段极性基因。我们在这里证明了这样一个基因，hedgehog，编码一种针对分泌途径的蛋白质，并与Engraded在胚胎和成像盘中表达一致；Hedgehog表达模式的维持本身依赖于其他片段极性基因，包括Engraded和Wingless。因此，Hedgehog的表达在位置信号中起作用，并对其敏感。这些特性与刺猬在角质层构图和维持无翅表达方面的非细胞自主要求是一致的。
The segment polarity genes engrailed and wingless are expressed in neighboring stripes of cells on opposite sides of the Drosophila parasegment boundary. Each gene is mutually required for maintenance of the other's expression; continued expression of both also requires several other segment polarity genes. We show here that one such gene, hedgehog, encodes a protein targeted to the secretory pathway and is expressed coincidently with engrailed in embryos and in imaginal discs; maintenance of the hedgehog expression pattern is itself dependent upon other segment polarity genes including engrailed and wingless. Expression of hedgehog thus functions in, and is sensitive to, positional signaling. These properties are consistent with the non-cell autonomous requirement for hedgehog in cuticular patterning and in maintenance of wingless expression.