Focal electrically administered therapy: device parameter effects on stimulus perception in humans.
Focal electrically administered therapy: device parameter effects on stimulus perception in humans.
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DOI：
10.1097/yct.0b013e318183c6a4
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发表时间：
2009-06
期刊：
影响因子：
--
通讯作者：
Sackeim HA
中科院分区：
文献类型：
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作者：
Borckardt JJ;Linder KJ;Ricci R;Li X;Anderson B;Arana A;Nahas Z;Amassian V;Long J;George MS;Sackeim HA
局灶性电刺激疗法(FEAT)是一种新型的经颅电刺激方法，具有局部调节脑活动的功能。除了对动物的侵入性研究和对人类运动输出的检查外，建立关于刺激参数的变化如何影响皮质内刺激模式的基本原理的可能性有限。这项研究使用了一个更简单的范式，评估了不同的刺激参数对头皮疼痛的性质和位置的主观知觉的影响。在两项研究中，19名受试者被随机刺激在左侧额头上，改变阴阳极排列、刺激强度、电极大小和位置，以及电流是单向的还是双向的。受试者对感觉的位置和质量进行了评分。感觉到的刺激中心向阴极移动，与位置无关。当电流是单向的时，这种主观感觉的转变更加明显。此外，更强烈的刺激，以及使用较小电极的刺激，会产生更大的知觉疼痛。单向刺激被认为在从大的阳极到小的阴极时更痛苦，而在从小的阳极到大的阴极的过程中痛苦较少。最后，当强度较高时，参与者更有可能感知到电刺激朝着特定方向移动，而不是当强度较小时。感觉的强度和位置可以通过改变电极的强度、电流方向或几何形状来控制。
Focal Electrically-Administered Therapy (FEAT) is a new method of transcranial electrical stimulation capable of focal modulation of cerebral activity. Other than invasive studies in animals and examination of motor output in humans, there are limited possibilities for establishing basic principles about how variation in stimulus parameters impact on patterns of intracortical stimulation. This study used a simpler paradigm, and evaluated the effects of different stimulation parameters on subjective perception of the quality and location of scalp pain. In two studies, 19 subjects were randomly stimulated over the left forehead, varying the anode-cathode arrangement, the intensity of stimulation, the electrode size and placement, and whether the current flow was unidirectional or bidirectional. Subjects rated the location of the sensation, and its quality. The perceived center of stimulation moved toward the cathode, regardless of placement. This shift in subjective sensation was more prominent when the electricity was unidirectional. Additionally, more intense stimulation, as well as stimulation with a smaller electrode, caused greater perceived pain. Unidirectional stimulation was rated more painful when traveling from a large anode to a small cathode and less painful when traveling from a small anode to a large cathode. Finally, participants were more likely to perceive the electrical stimulation as moving towards a specific direction when the intensity was high than when it was low. The intensity and location of sensations can be manipulated by varying the intensity, current direction, or geometry of electrodes.