Effects of vitamin D insufficiency on bone mineral density in African American men
Effects of vitamin D insufficiency on bone mineral density in African American men
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DOI：
10.1007/s00198-008-0746-4
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发表时间：
2009-05-01
影响因子：
4
通讯作者：
Barengolts, E.
中科院分区：
文献类型：
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作者：
Akhter, N.;Sinnott, B.;Barengolts, E.
在非裔美国男性血清中，89%的受试者的25-羟基维生素D（25-OHD）低于30 ng/ml。在总体组中，25-OHD与骨密度（BMD）无相关性。对25-OHD（15 ng/ml）的受试者进行亚组分析表明，血清25-OHD与BMD呈正相关。来自市中心退伍军人管理局医疗中心的普通医学诊所的男性。112名AA男性的数据，他们都有25-采用SAS软件对AA患者的OHD水平、脊柱和髋部骨密度进行分析。25-OHD水平范围为4 - 45 ng/ml，平均17.5 ng/ml，24%和89%的受试者的25-OHD分别低于10和30 ng/ml。在整个组中，25-OHD与任何部位的BMD之间均不存在相关性。在对25-OHD a千分之一货币符号15 ng/ml受试者的亚组分析中，在多个校正模型中，25-OHD与脊柱BMD呈正相关（r = 0.26，p = 0.05），全髋关节（r = 0.27，p < 0.05），Ward三角形（r = 0.25，p = 0.05）和转子（r = 0.30，p < 0.05）。维生素D不足对骨的负面影响仅在非常低的25-OHD水平下观察到，提示AA男性骨骼对继发性甲状旁腺功能亢进的影响具有相对抵抗力。
In African American men serum, 25-hydroxyvitamin D (25-OHD) was below 30 ng/ml in 89% of subjects. In overall group, there was no correlation between 25-OHD and bone mineral density (BMD). A subgroup analysis of subjects with 25-OHD a parts per thousand currency sign15 ng/ml showed that serum 25-OHD was positively associated with BMD.This study examined the effects of low serum 25-hydroxyvitamin D (25-OHD) on bone mineral density (BMD) in African American (AA) men from the general medicine clinic at an inner city Veteran Administration medical center.The data for 112 AA males who had both 25-OHD levels and BMD of spine and hip were extracted and analyzed using SAS software.AA men were aged 38 to 85 years, with mean age of 62 years. Levels of 25-OHD ranged from 4 to 45 ng/ml, with mean 17.5 ng/ml, 24% and 89% of the subjects had 25-OHD below 10 and 30 ng/ml, respectively. In the overall group, there was no correlation between 25-OHD and BMD at any site. In a subgroup analysis of subjects with 25-OHD a parts per thousand currency sign15 ng/ml, in multiple adjusted models, 25-OHD was positively associated with BMD of spine (r = 0.26, p = 0.05), total hip (r = 0.27, p < 0.05), ward's triangle (r = 0.25, p = 0.05), and trochanter (r = 0.30, p < 0.05).The negative effect of vitamin D insufficiency on bone was observed only at very low levels of 25-OHD, suggesting that AA male skeleton is relatively resistant to the effects of secondary hyperparathyroidism.