Effect of arginine on insulin release in vitro.
Effect of arginine on insulin release in vitro.
复制标题
精氨酸对体外胰岛素释放的影响。
DOI：
10.1016/0026-0495(69)90100-0
复制
发表时间：
1969
期刊：
影响因子：
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通讯作者：
E. Almogela
中科院分区：
文献类型：
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作者：
P. Edgar;D. Rabinowitz;T. Merimee;E. Almogela
本文通过观察葡萄糖和精氨酸单独及联合作用对兔胰腺片在碳酸氢盐缓冲液中释放免疫胰岛素的影响，研究了精氨酸对胰岛素释放的影响。单独的精氨酸（1.0-3.0 mg./ ml.）未能刺激胰岛素释放高于对照水平，而当随后暴露于3.0或3.5 mg. ml.做出了令人信服的回应当在1.5 mg./L精氨酸的缓冲液中进行试验时，ml.葡萄糖，它显着增强胰岛素的释放。这些数据表明精氨酸通过增强葡萄糖代谢物的刺激作用影响胰岛素释放，葡萄糖代谢物触发B细胞中的胰岛素释放。
The effect of arginine on insulin release was studied by observing the effect of glucose and arginine, both singly and together, on the release of immuno insulin from pieces of rabbit pancreas incubated in bicarbonate buffer. Arginine alone (1.0–3.0 mg./ml.) failed to stimulate insulin release above control levels, whereas the same pancreas when subsequently exposed to a glucose concentration of 3.0 or 3.5 mg./ml. showed a convincing response. When ariginine was tested in buffer fortified with 1.5 mg./ml. glucose, it significantly enhanced insulin release. These data suggest that arginine influences insulin release by enhancing the stimulatory effect of the glucose metabolite(s) which triggers insulin release in the B-cell.