Hepatoprotective effect of Handaeri-gomchi (Ligularia fischeri var. spiciformis Nakai) extract against chronic alcohol-induced liver damage in rats
Hepatoprotective effect of Handaeri-gomchi (Ligularia fischeri var. spiciformis Nakai) extract against chronic alcohol-induced liver damage in rats
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DOI：
10.1007/s10068-011-0228-x
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发表时间：
2011-12
影响因子：
2.9
通讯作者：
Ji-Hye Yoo;Sarangerel Oidovsambuu;Sang Min Kim;N. Jeon;J. Yun;K. Kang;E. Jho;Saet Byoul Lee;C. Nho
中科院分区：
文献类型：
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作者：
Ji-Hye Yoo;Sarangerel Oidovsambuu;Sang Min Kim;N. Jeon;J. Yun;K. Kang;E. Jho;Saet Byoul Lee;C. Nho
Handaeri-gomchi（Ligularia fischerivar.spiciformisNakai）（LF）在韩国作为药用植物是众所周知的，特别是用于治疗包括肝功能衰竭在内的多种人类疾病。在这项研究中，我们研究了LF提取物对肝脏损伤和氧化应激的活性，慢性酒精在Spargue-Dawley大鼠。在喂食LF提取物的大鼠组中，酒精摄入引起的严重肝损伤随着肝脏标志物活性的增加而减少。结果通过苏木精和伊红染色证实。抗氧化能力降低乙醇，但它恢复LF提取物。在LF提取物组中，慢性酒精引起的氧化应激指标升高有所减少。此外，LF提取物提高抗氧化能力和抗氧化酶的活性。总之，LF提取物对慢性酒精肝毒性具有保护作用，表明其可开发为保护肝脏疾病的功能性食品或药物。
Handaeri-gomchi(Ligularia fischerivar.spiciformisNakai) (LF) is well known as a medicinal plant in Korea, especially to treat a variety of human disease including hepatic function failure. In this study, we examined the activity of LF extract against the liver injuries and oxidative stress by chronic alcohol in Spargue-Dawley rats. Severe liver damage caused by alcohol intake with increasing activity of hepatic markers was decreased in the group of rats fed LF extract. The results were confirmed through hematoxylin and eosin staining. Antioxidative capacity was decreased by alcohol but it was recovered by LF extract. Elevated indicators of oxidative stress by chronic alcohol were diminished in the group of LF extract. Furthermore, LF extracts increased antioxidative capacity and the activity of antioxidant enzymes. In conclusion, LF extract has a protective effect against chronic alcohol hepatotoxicity, suggesting it could be developed as a functional food or medicine for protection of liver disease.