The integrin α4β7 forms a complex with cell-surface CD4 and defines a T-cell subset that is highly susceptible to infection by HIV-1
The integrin α4β7 forms a complex with cell-surface CD4 and defines a T-cell subset that is highly susceptible to infection by HIV-1
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DOI：
10.1073/pnas.0911796106
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发表时间：
2009-12-08
影响因子：
11.1
通讯作者：
Arthos, James
中科院分区：
文献类型：
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作者：
Cicala, Claudia;Martinelli, Elena;Arthos, James
粘膜组织中激活的和静止的CD4(+)T细胞在HIV-1性传播后感染的早期阶段发挥着重要作用，这是一个效率低下的过程。HIV-1gp120与肠道粘膜归巢受体整合素α(4)β(7)(α(4)β(7))结合。我们发现，α(4)β(高)(7)CD4(+)T细胞比α(4)β(低阴性)(7)CD4(+)T细胞更容易受到生产性感染，部分原因是这个细胞亚群富含代谢活性的CD4(+)T细胞。α(4)β(高)(7)CD4(+)T细胞是CCR5(高)和CXCR4(低)；在这些细胞上，α(4)β(7)出现在与CD4的复合体中。Gp120对α(4)β(7)的特异性亲和力为HIV-1提供了一种针对激活细胞的机制，这些激活细胞对病毒的有效繁殖和性传播后的传播至关重要。
Both activated and resting CD4(+) T cells in mucosal tissues play important roles in the earliest phases of infection after sexual transmission of HIV-1, a process that is inefficient. HIV-1 gp120 binds to integrin alpha(4)beta(7) (alpha(4)beta(7)), the gut mucosal homing receptor. We find that alpha(4)beta(high)(7) CD4(+) T cells are more susceptible to productive infection than are alpha(4)beta(low-neg)(7) CD4(+) T cells in part because this cellular subset is enriched with metabolically active CD4(+) T cells. alpha(4)beta(high)(7) CD4(+) T cells are CCR5(high) and CXCR4(low); on these cells, alpha(4)beta(7) appears in a complex with CD4. The specific affinity of gp120 for alpha(4)beta(7) provides a mechanism for HIV-1 to target activated cells that are critical for efficient virus propagation and dissemination following sexual transmission.