Sex steroid hormone exposures and risk for meningioma
Sex steroid hormone exposures and risk for meningioma
复制标题
DOI：
10.3171/jns.2003.99.5.0848
复制
发表时间：
2003-11-01
影响因子：
4.1
通讯作者：
Stampfer, MJ
中科院分区：
文献类型：
--
作者：
Jhawar, BS;Fuchs, CS;Stampfer, MJ
物体。这项研究的目的是调查脑膜瘤的风险与外源性和内源性性激素的关系。研究参与者是来自美国I I州的注册女护士，她们参加护士健康研究队列时的年龄在30岁到55岁之间。这些妇女在1976年至1996年期间完成了两年一次的问卷调查。在研究开始时，所有参与者都没有癌症和其他重大疾病。主要终点是脑膜瘤，在两年一次和补充调查问卷中自我报告。在1213522人年的随访中，125例脑膜瘤得到确认。在调整了年龄和体重指数(BMI)后，与从未使用过绝经后激素的绝经后妇女相比，绝经前妇女的相对危险度(RR)为2.48(95%可信区间[CI]1.29~4.77；P=0.01)，接受激素治疗的绝经后妇女的相对危险度(RR)为1.86(95%CI为1.07~3.24；P=0.03)。作者发现，过去使用激素没有额外的风险。在另外控制激素使用和绝经状态的模型中，作者发现，与月经初潮发生在12岁之前的女性相比，月经初潮发生在12岁至14岁的女性的相对危险度为1.29(95%可信区间0.86-1.92；p=0.21)，月经初潮发生在14岁之后的女性的相对危险度为1.97(95%可信区间1.06-3.66；p=0.03)。作者还观察到，与未分娩的妇女相比，产妇患脑膜瘤的风险有增加的趋势，尽管不显著(多变量RR=2.39，95%CI 0.76-7.53；p=0.14)。随着BMI的增加，脑膜瘤的风险也有增加的趋势(趋势=0.06)。没有发现与过去或现在使用口服避孕药有关。在暴露于内源性或外源性性激素的女性中，患脑膜瘤的风险增加。还注意到了与月经初潮年龄增加的意外关系；这一点仍未得到解释。
Object. The goal of this study was to investigate the risk of meningioma in relation to exogenous and endogenous sex hormones.Methods. The study participants were female registered nurses from I I US states who were between 30 and 55 years of age when they enrolled in the Nurses' Health Study cohort. These women completed biennial questionnaires between 1976 and 1996. All participants were free from cancer and other major medical illness at the onset of the study. The primary endpoint was meningioma as self-reported in biennial and supplemental questionnaires.During 1,213,522 person-years of follow-up review, 125 cases of meningioma were confirmed. After adjusting for age and body mass index (BMI), compared with postmenopausal women who had never used postmenopausal hormones, the relative risk (RR) for premenopausal women was 2.48 (95% confidence interval [CI] 1.29-4.77; p = 0.01) and the RR for postmenopausal women who received hormone therapy was 1.86 (95% CI 1.07-3.24; p = 0.03). The authors found no excess risk associated with past hormone use. In models that additionally controlled for hormone use and menopausal status, the authors found that, compared with women whose menarche occurred before they were 12 years of age, the RR for women whose menarche occurred at ages 12 through 14 years was 1.29 (95% CI 0.86-1.92; p = 0.21) and the RR for women whose menarche occurred after age 14 years was 1.97 (95% Cl 1.06-3.66; p = 0.03). The authors also observed a tendency, albeit nonsignificant, for increased risk of meningioma in parous as opposed to nulliparous women (multivariate RR = 2.39, 95% Cl 0.76-7.53; p = 0.14). A trend toward an increasing risk of meningioma with increasing BMI was also noted (p for trend = 0.06). No association was found for past or current use of oral contraceptives.Conclusions. The risk for meningiomas was increased among women exposed to either endogenous or exogenous sex hormones. An unexpected relationship with increasing age at menarche was also noted; this remains unexplained.