Prognostic significance of SOX18 expression in non-small cell lung cancer
Prognostic significance of SOX18 expression in non-small cell lung cancer
复制标题
DOI：
10.3892/ijo.2014.2698
复制
发表时间：
2015-01-01
影响因子：
5.2
通讯作者：
Podhorska-Okolow, Marzena
中科院分区：
文献类型：
--
作者：
Jethon, Aleksandra;Pula, Bartosz;Podhorska-Okolow, Marzena
最近的研究表明，SOX 18转录因子参与血液和淋巴管的发展，以及在伤口愈合过程。已经在包括肺癌在内的各种肿瘤的癌细胞中注意到S 0X 18表达。然而，SOX 18表达在非小细胞肺癌（NSCLC）中的确切作用仍有待确定。因此，本研究评估了其在198例NSCLC中的表达，包括94例腺癌（AC），89例鳞状细胞癌（SQC）和15例大细胞癌（LCC）。分析采用免疫组化（IHC），并在42例，分子方法。还在NSCLC细胞系（NCI-H1703、NCI-H522和A549）和正常肺成纤维细胞（IMR-90）中测定了S 0X 18表达。在大多数研究病例中，发现SOX 18在癌细胞的细胞核和细胞质中表达。SOX 18 mRNA在NSCLC中的表达明显低于非癌肺组织（P
Recent studies have demonstrated the involvement of SOX18 transcription factor in blood and lymphatic vessel development, as well as in wound healing processes. SOX18 expression has been noted in cancer cells of various tumours, including lung cancer. However, the exact role of SOX18 expression in non-small cell lung cancer (NSCLC) remains to be determined The present study, therefore, assessed its expression in 198 cases of NSCLC, consisting of 94 adenocarcinomas (AC), 89 squamous cell carcinomas (SQC) and 15 large cell carcinomas (LCC). The analysis utilized immunohistochemistry (IHC) and, in 42 cases, molecular methods. SOX18 expression was also determined in NSCLC cell lines (NCI-H1703, NCI-H522 and A549) and in normal lung fibroblasts (IMR-90). SOX18 was found to be expressed in nuclei, as well as in the cytoplasm of cancer cells, in the majority of studied cases. SOX18 mRNA expression was significantly lower in NSCLC than in non-malignant lung tissue (P