Genetic analysis of the corticosterone response to ethanol in BXD recombinant inbred mice.
Genetic analysis of the corticosterone response to ethanol in BXD recombinant inbred mice.
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BXD 重组近交小鼠皮质酮对乙醇反应的遗传分析。
DOI：
10.1037//0735-7044.109.6.1199
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发表时间：
1995
影响因子：
1.9
通讯作者：
Keith,LD
中科院分区：
文献类型：
--
作者：
Roberts,AJ;Phillips,TJ;Belknap,JK;Finn,DA;Keith,LD
用C57 BL/6 J（B6）和DBA/2 J（D2）的F2代杂交的BXD重组自交系（RI）研究了皮质酮对乙醇（EtOH）反应的遗传控制及其与其他EtOH相关性状的可能关系。定量性状基因座（QTL）分析皮质酮水平1小时后乙醇建议对这一性状的影响，一个单一的主基因。两个位点预测占47%的遗传变异的血浆皮质酮水平6小时后乙醇，而3个位点预测占78%的遗传变异的皮质酮水平7小时后乙醇。标记物与皮质酮水平7小时后EtOH和校正皮质酮水平6小时后EtOH重叠，发现影响急性和慢性EtOH戒断的严重程度，这表明这些性状之间一定程度的共同遗传决定。总的来说，这些结果表明，基因的作用显着影响压力反应，并建议这些基因可能的染色体位置。（PsycInfo数据库记录（c）2022阿帕，保留所有权利）
The genetic control over the corticosterone response to ethanol (EtOH) and its possible relationship to other EtOH-related traits was examined using BXD recombinant inbred (RI) strains derived from an F2 cross of C57BL/6J (B6) and DBA/2J (D2) progenitor strains. Quantitative trait locus (QTL) analysis of corticosterone levels 1 hr following EtOH suggested the influence of a single major gene on this trait. Two loci were predicted to account for 47% of the genetic variance in plasma corticosterone levels 6 hr following EtOH, whereas 3 loci were predicted to account for 78% of the genetic variance in corticosterone levels 7 hrs following EtOH. Markers associated with corticosterone levels 7 hrs following EtOH and corrected corticosterone levels 6 hrs post-EtOH overlapped with ones found to influence acute and chronic EtOH withdrawal severity, suggesting some degree of common genetic determination between these traits. Overall these results indicate that gene action significantly influences stress responsiveness and suggest possible chromosomal locations of these genes.(PsycInfo Database Record (c) 2022 APA, all rights reserved)
近交系小鼠的起源。
DOI：
10.1016/b978-0-12-507850-4.x5001-x
发表时间：
1978
期刊：
Revue de Médecine Interne
影响因子：
--
作者：
H. Morse
通讯作者：
H. Morse