Multicenter study of carbon-ion radiation therapy for nonsquamous cell carcinomas of the oral cavity.
Multicenter study of carbon-ion radiation therapy for nonsquamous cell carcinomas of the oral cavity.
复制标题
碳离子放射治疗口腔非鳞状细胞癌的多中心研究。
DOI：
10.1002/cam4.2408
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Kamada T.
中科院分区：
文献类型：
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作者：
Ikawa H;Koto M;Demizu Y;Saitoh JI;Suefuji H;Okimoto T;Ohno T;Shioyama Y;Takagi R;Hayashi K;Nemoto K;Nakano T;Kamada T.
BackgroundThe的目的是评估的有效性和安全性的碳离子放射治疗口腔非鳞状细胞癌的多中心研究MethodsRetrospective分析的临床病理特征和结果的76例口腔非鳞状细胞癌与N 0 - 1 M0状态和治疗与碳离子放射治疗在2003年11月和12月之间在日本的四个机构结果涎腺癌、粘膜黑色素瘤和其他三种癌分别见于46例、27例和3例患者。T1 - 3、T4 a和T4 b疾病分别诊断为27、18和31例患者。中位随访期为31.1个月（范围：3 - 118个月）。所有患者的3年局部控制率、无进展生存率和总生存率分别为86.8%、63.1%和78.4%。多因素分析显示，T分期（T4）是局部控制的一个重要的独立预后不良因素。在38例患者中观察到急性3级粘膜炎。分别在9例和4例患者中观察到3级和4级晚期发病率。无5级晚期毒副反应。结论口腔非鳞状细胞癌可以有效治疗，可接受的毒性，通过碳离子放射治疗。
BackgroundThe aim of this study was to evaluate the efficacy and safety of carbon‐ion radiation therapy for nonsquamous cell carcinomas of the oral cavity in a multicenter study.MethodsRetrospective analysis of the clinicopathological features and outcomes of 76 patients with oral nonsquamous cell carcinomas with N0‐1 M0 status and were treated with carbon‐ion radiation therapy at four institutions in Japan between November 2003 and December 2014 was performed.ResultsSalivary gland carcinoma, mucosal melanoma, and three other carcinomas were found in 46, 27, and 3 patients, respectively. T1‐3, T4a, and T4b disease was diagnosed in 27, 18, and 31 patients, respectively. Median follow‐up period was 31.1 months (range, 3‐118 months). Three‐year local control, progression‐free survival, and overall survival of all patients were 86.8%, 63.1%, and 78.4%, respectively. Multivariate analysis showed T classification (T4) to be a significant independent poor prognostic factor for local control. Acute grade 3 mucositis was observed in 38 patients. Grades 3 and 4 late morbidities were observed in 9 and 4 patients, respectively. No grade 5 late toxicity was observed.ConclusionsOral nonsquamous cell carcinomas could be treated effectively, with acceptable toxicity, by carbon‐ion radiation therapy.