Influence of pentobarbital anesthesia on the effects of certain autonomic blocking agents on heart rate.
Influence of pentobarbital anesthesia on the effects of certain autonomic blocking agents on heart rate.
复制标题
戊巴比妥麻醉对某些自主神经阻滞剂对心率影响的影响。
DOI：
10.1016/0014-2999(73)90084-8
复制
发表时间：
1973
影响因子：
5
通讯作者：
B. Jandhyala
中科院分区：
文献类型：
--
作者：
M. Lokhandwala;I. Cavero;J. Buckley;B. Jandhyala
在杂种犬中，戊巴比妥麻醉显著改变了心肌的神经原性控制。由于各种自主神经阻滞剂的药理学反应基本上取决于这种神经性控制，它们对心率的影响在清醒动物中与戊巴比妥麻醉下的动物显著不同。戊巴比妥钠可明显降低自发心率，提示戊巴比妥钠对S-A结有直接阻断作用。
The nature of neurogenic control of the myocardium was profoundly altered by pentobarbital anesthesia in mongrel dogs. Since the pharmacological responses of various autonomic blocking agents depend essentially upon this neurogenic control, their effects on cardiac rate were significantly different in conscious animals from those under pentobarbital anesthesia. The intrinsic heart rate was significantly attenuated by pentobarbital suggesting that it had direct depressant effect on S-A node.