The VDAC channel: Molecular basis for selectivity
The VDAC channel: Molecular basis for selectivity
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DOI：
10.1016/j.bbamcr.2016.01.019
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发表时间：
2016-10-01
影响因子：
5.1
通讯作者：
Colombini, Marco
中科院分区：
文献类型：
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作者：
Colombini, Marco
电压依赖性阴离子选择通道(VDAC)是分子和离子通过线粒体外膜的主要通透途径。这种途径的进化是为了优化这些物质的流动，并通过受包括跨膜电压在内的各种因素影响的门控过程来控制这种流动。VDAC通过膜形成的渗透途径是复杂的。小离子流主要受通道内壁带电表面的影响。通道关闭改变了这种情况，导致通道从有利于阴离子的通道改变为有利于阳离子的通道。分子离子与通道内壁的相互作用更紧密，并通过它们的三维结构来选择，而不仅仅是它们的大小和电荷。通常存在于细胞中的分子离子比那些不存在这些较大结构的分子离子更受青睐该通道可能形成一条低能量的易位路径，与预想的结构相辅相成本文是由Pierre Sonveaux，Pierre Maechler和Jean-Claude Martinou编辑的题为：线粒体通道的特刊的一部分。(C)2016爱思唯尔B.V.保留所有权利。
The voltage dependent anion-selective channel, VDAC, is the major permeability pathway by which molecules and ion cross the mitochondrial outer membrane. This pathway has evolved to optimize the flow of these substances and to control this flow by a gating process that is influenced by a variety of factors including transmembrane voltage. The permeation pathway formed through the membrane by VDAC is complex. Small ion flow is primarily influenced by the charged surface of the inner walls of the channel. Channel closure changes this landscape resulting in a change from a channel that favors anions to one that favors cations. Molecular ions interact more intimately with the inner walls of the channel and are selected by their 3-dimensional structure, not merely by their size and charge. Molecular ions typically found in cells are greatly favored over those that are not For these larger structures the channel may form a low-energy translocation path that complements the structure of the permeant This article is part of a Special Issue entitled: Mitochondrial Channels edited by Pierre Sonveaux, Pierre Maechler and Jean-Claude Martinou. (C) 2016 Elsevier B.V. All rights reserved.