Prognostic value of preoperative peripheral blood monocyte count in patients with colorectal liver metastasis after liver resection
Prognostic value of preoperative peripheral blood monocyte count in patients with colorectal liver metastasis after liver resection
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DOI：
10.1007/s11605-007-0140-0
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发表时间：
2007-05-01
影响因子：
3.2
通讯作者：
Kitano, Seigo
中科院分区：
文献类型：
--
作者：
Sasaki, Atsushi;Kai, Seiichiro;Kitano, Seigo
癌症患者外周血中白细胞亚群计数的预后价值尚未得到充分的研究。对97例结直肠癌肝转移行肝切除术患者的术前外周血白细胞亚群绝对计数与临床病理因素及远期预后的关系进行了回顾分析。术前外周血白细胞中位数：中性粒细胞3148/mm(3例)，淋巴细胞1574/mm(3例)，单核细胞380/mm(3例)。单变量分析表明，外周血单核细胞计数为300/mm(3)的患者的5年癌症相关生存率(67.5%)明显低于外周血单核细胞计数为300/mm(3)且术前CEA水平(>；10 ng/ml)为肝切除后癌症相关生存的独立预测因素的患者。术前外周血单核细胞计数与外周血白细胞、中性粒细胞计数呈正相关，与肿瘤个数、结、肝手术间隔时间及术前血清CEA水平无相关性。我们的研究结果表明，术前外周血单核细胞绝对值为300/mm(3)是接受肝切除术的结直肠癌肝转移患者癌症相关生存的独立预测因素。
Prognostic values of leukocyte subset counts in peripheral blood of cancer patients have not yet been fully investigated. We retrospectively examined the relation between preoperative absolute counts of peripheral blood leukocyte subsets and clinicopathologic factors and long-term prognosis in 97 patients with liver metastasis from colorectal cancer who underwent hepatic resection. Median preoperative peripheral blood leukocyte subset counts were as follows: neutrophils 3148/mm(3); lymphocytes 1574/mm(3); monocytes 380/mm(3). Univariate analysis indicated significantly worse 5-year cancer-related survival for patients with a peripheral blood monocyte count > 300/ mm(3) (67.5%) than for patients with a count 300/ mm(3) and preoperative CEA level (> 10 ng/ml) to be independent predictive factors for cancer-related survival after hepatic resection. The preoperative peripheral monocyte count correlated positively with white blood cell and neutrophil counts, but not with the tumor number, interval between colorectal and hepatic surgery, or preoperative serum CEA level. Our findings indicate that a preoperative absolute peripheral blood monocyte count > 300/ mm(3) is an independent predictive factor for cancer-related survival of patients with colorectal liver metastasis who have undergone hepatic resection.