Prognostic significance of E-cadherin protein expression in pathological stage I-III endometrial cancer
Prognostic significance of E-cadherin protein expression in pathological stage I-III endometrial cancer
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DOI：
10.1158/1078-0432.ccr-0943-03
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发表时间：
2004-08-15
影响因子：
11.5
通讯作者：
Mundt, AJ
中科院分区：
文献类型：
--
作者：
Mell, LK;Meyer, JJ;Mundt, AJ
目的：E-cadherin在子宫内膜癌细胞中表达降低与不良预后特征相关。本研究的目的是评估E-cadherin的表达减少在子宫内膜癌患者的预后意义。实验设计：在1992年和1999年之间，102子宫内膜癌患者的I-III期疾病进行了主要手术在芝加哥大学。代表性的组织标本进行免疫染色的单克隆抗体E-钙粘蛋白。根据E-cadherin膜染色的子宫内膜癌细胞百分比，制定了半定量评估量表。如果> 75%，则组织切片评分为“3”，如果25- 75%，则评分为64299，如果5- 25%，则评分为“1”，并且如果25- 75%，则评分为“0”。
Purpose: Decreased expression of E-cadherin in endometrial cancer cells is associated with adverse prognostic features. This study aimed to evaluate the prognostic significance of decreased E-cadherin expression in patients with endometrial cancer.Experimental Design: Between 1992 and 1999, 102 endometrial cancer patients with stage I-III disease underwent primary surgery at the University of Chicago. Representative tissue specimens were immunostained with a monoclonal antibody to E-cadherin. A semiquantitative evaluation scale was developed based on the percentage of endometrial cancer cells with membranous E-cadherin staining. Tissue sections were scored as "3" if >75%, 64299 if 25-75%, "1" if 5-25%, and "0" if