Oral rehydration therapy: new explanations for an old remedy.
Oral rehydration therapy: new explanations for an old remedy.
复制标题
口服补液疗法：旧疗法的新解释。
DOI：
10.1146/annurev.physiol.66.032902.134726
复制
发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Rao,MrinaliniC
中科院分区：
文献类型：
--
作者：
Rao,MrinaliniC
腹泻病是全球最具破坏性的疾病之一，但口服补液疗法的引入使因腹泻造成的死亡率从1978年的500万5岁以下儿童减少到2002年的130万。在世界各地的文化中，这种简单的盐和糖疗法的变体在传统疗法中很普遍，但直到过去40年，这些疗法的科学基础才开始被阐明。这篇综述旨在提供对口服补液疗法的细胞学基础的广泛了解。口服补液治疗成功的关键是小肠中葡萄糖的活跃运输、共生菌和结肠中的短链脂肪酸运输。该综述检查了这些过程及其调节，并考虑了在控制腹泻疾病方面可能补充口服补液疗法的新方法。
Diarrheal diseases are among the most devastating illnesses globally, but the introduction of oral rehydration therapy has reduced mortality due to diarrhea from> 5 million children, under the age of 5, in 1978 to 1.3 million in 2002. Variations of this simple therapy of salts and sugars are prevalent in traditional remedies in cultures world-wide, but only in the past four decades have the scientific bases for these remedies begun to be elucidated. This review aims to provide a broad understanding of the cellular basis of oral rehydration therapy. The features integral to the success of oral rehydration therapy are active glucose transport in the small intestine, commensal bacteria, and short-chain fatty acid transport in the colon. The review examines these processes and their regulation and considers new approaches that might supplement oral rehydration therapy in controlling diarrheal diseases.