Insulin-like growth factor-1 ameliorates age-related behavioral deficits
Insulin-like growth factor-1 ameliorates age-related behavioral deficits
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DOI：
10.1016/s0306-4522(98)00143-2
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发表时间：
1998-12-01
期刊：
影响因子：
3.3
通讯作者：
Sonntag, WE
中科院分区：
文献类型：
--
作者：
Markowska, AL;Mooney, M;Sonntag, WE
胰岛素样生长因子-1（insulin-likegrowthfactor-1，IGF-1）参与脑代谢、神经传递、神经生长和分化等多个方面的调节。由于胰岛素样生长因子-1和/或其受体的减少可能导致年龄相关的行为异常，因此替代这种蛋白质的策略是一种潜在的治疗选择。本研究的目的是评估随着年龄的增长，认知缺陷是否可以通过增加大脑中胰岛素样生长因子-1的可用性来部分克服。两个年龄（4个月大和32个月大）的Fischer-344 x Brown Norway杂交（F1）雄性大鼠在术前接受行为任务训练，随后植入渗透性微型泵以输注胰岛素样生长因子-1（23.5 μ g/泵）或溶媒（i. c. v.）。在术后2周和4周对动物进行重新测试。胰岛素样生长因子-1在重复获取任务和物体识别任务中改善了工作记忆。在评估参考记忆的位置辨别任务中也观察到了改善。胰岛素样生长因子-1对感觉运动技能和探索能力无影响。这些数据表明胰岛素样生长因子-1在逆转啮齿类动物年龄相关行为障碍中具有潜在的重要作用。(C)1998年IBRO。出版社：Elsevier Science Ltd
Insulin-like growth factor-1 has been found to be involved in the regulation of several aspects of brain metabolism neural transmission, neural growth and differentiation. Because decreased insulinlike growth factor-1 and/or its receptors are likely to contribute to age-related abnormalities in behavior, the strategy of replacing this protein is one potential therapeutic alternative. The present study was designed to assess whether cognitive deficits with ageing may be partially overcome by increasing the availability of insulin-like growth factor-1 in the brain. Fischer-344 x Brown Norway hybrid (F1) male rats of two ages (four-months-old and 32-months-old) were preoperatively trained in behavioral tasks and subsequently implanted with osmotic minipumps to infuse the insulin-like growth factor-1 (23.5 mu g/pump) or a vehicle, i.c.v. Animals were retested at two weeks and four weeks after surgery. Insulin-like growth factor-1 improved working memory in the repeated acquisition task and in the object recognition task. An improvement was also observed in the place discrimination task, which assesses reference memory. Insulin-like growth factor-1 bad no effect on sensorimotor skills nor exploration. but mildly reversed some age-related deficits in emotionality.These data indicate a potentially important role for insulin-like growth factor-1 in the reversal of age-related behavioral impairments in rodents. (C) 1998 IBRO. Published by Elsevier Science Ltd.