Higenamine Attenuates Neuropathic Pain by Inhibition of NOX2/ROS/TRP/P38 Mitogen-Activated Protein Kinase/NF-ĸB Signaling Pathway.
Higenamine Attenuates Neuropathic Pain by Inhibition of NOX2/ROS/TRP/P38 Mitogen-Activated Protein Kinase/NF-ĸB Signaling Pathway.
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去甲乌药碱通过抑制 NOX2/ROS/TRP/P38 丝裂原激活蛋白激酶/NF-äB 信号通路减轻神经性疼痛
DOI：
10.3389/fphar.2021.716684
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发表时间：
2021
影响因子：
5.6
通讯作者：
Zhao G
中科院分区：
文献类型：
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作者：
Yang B;Ma S;Zhang C;Sun J;Zhang D;Chang S;Lin Y;Zhao G
Oxidative stress damage is known as one of the important factors that induce neuropathic pain (NP). Using antioxidant therapy usually achieves an obvious curative effect and alleviates NP. Previous pharmacological studies have shown that higenamine (Hig) performs to be antioxidant and anti-inflammatory. However, the protective effect and mechanism of Hig on NP are still unclear. This study mainly evaluated the changes in reactive oxygen species (ROS) level, lipid peroxidation, and antioxidant system composed of superoxide dismutase (SOD) and glutathione (GSH) through chronic constrict injury (CCI) model rats and t-BHP-induced Schwann cell (SC) oxidative stress model. The expressions of two inflammatory factors, tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6), were also assessed. The possible molecular mechanism of Hig in the treatment of NP was explored in conjunction with the expression of mitochondrial apoptosis pathway and NOX2/ROS/TRP/P38 mitogen-activated protein kinase (MAPK)/NF-ĸB pathway-related indicators. Hig showed substantial antioxidant and anti-inflammatory properties both in vivo and in vitro. Hig significantly reduced the upregulated levels of ROS, malondialdehyde (MDA), TNF-α, and IL-6 and increased the levels of SOD and GSH, which rebalanced the redox system and improved the survival rate of cells. In the animal behavioral test, it was also observed that Hig relieved the CCI-induced pain, indicating that Hig had a pain relief effect. Our research results suggested that Hig improved NP-induced oxidative stress injury, inflammation, and apoptosis, and this neuroprotective effect may be related to the NOX2/ROS/TRP/P38 MAPK/NF-ĸB signaling pathway.
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影响因子：
--
作者：
Cifuentes-Pagano E;Saha J;Csányi G;Ghouleh IA;Sahoo S;Rodríguez A;Wipf P;Pagano PJ;Skoda EM
通讯作者：
Skoda EM
影响因子：
4.6
作者：
Kistner K;Siklosi N;Babes A;Khalil M;Selescu T;Zimmermann K;Wirtz S;Becker C;Neurath MF;Reeh PW;Engel MA
通讯作者：
Engel MA
影响因子：
81.5
作者：
Colloca, Luana;Ludman, Taylor;Raja, Srinivasa N.
通讯作者：
Raja, Srinivasa N.
影响因子：
7.2
作者：
Lee, Gyeongbeen;Choi, Jiwon;Choi, Yongmun
通讯作者：
Choi, Yongmun
DOI：
10.1038/nrd2757
发表时间：
2009-01
期刊：
Nature reviews. Drug discovery
影响因子：
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作者：
通讯作者：
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