Norovirus disease in the United States.
Norovirus disease in the United States.
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DOI：
10.3201/eid1908.130465
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发表时间：
2013-08
影响因子：
11.8
通讯作者：
Parashar UD
中科院分区：
文献类型：
--
作者：
Hall AJ;Lopman BA;Payne DC;Patel MM;Gastañaduy PA;Vinjé J;Parashar UD
尽管诺沃克病毒被认为是所有年龄段的流行性急性胃肠炎的主要原因，但就其地方性疾病发病率而言，诺沃克病毒的特点仍然很差。在最近的几项研究中，使用了不同的方法，包括归因比例外推、基于人群的监测和间接建模，大大改善了美国诺沃克病毒病发病率的估计。诺沃克病毒每年平均导致570-800人死亡，56,000-71,000人住院，400,000人急诊，170-190万人门诊，总疾病1900-2100万人。65岁的人与诺沃克病毒相关的死亡风险最大，5岁的儿童与诺沃克病毒相关的医疗就诊率最高。地方性诺沃克病毒病常年发生，但表现出明显的冬季高峰期，并在出现大流行毒株的年份增加≤50%。这些发现支持继续开发和瞄准适当的干预措施，包括疫苗，以治疗诺沃克病毒病。
Although recognized as the leading cause of epidemic acute gastroenteritis across all age groups, norovirus has remained poorly characterized with respect to its endemic disease incidence. Use of different methods, including attributable proportion extrapolation, population-based surveillance, and indirect modeling, in several recent studies has considerably improved norovirus disease incidence estimates for the United States. Norovirus causes an average of 570–800 deaths, 56,000–71,000 hospitalizations, 400,000 emergency department visits, 1.7–1.9 million outpatient visits, and 19–21 million total illnesses per year. Persons >65 years of age are at greatest risk for norovirus-associated death, and children <5 years of age have the highest rates of norovirus-associated medical care visits. Endemic norovirus disease occurs year round but exhibits a pronounced winter peak and increases by ≤50% during years in which pandemic strains emerge. These findings support continued development and targeting of appropriate interventions, including vaccines, for norovirus disease.