Host-Specific Differences in Gut Microbiota Between Cricetulus barabensis and Phodopus sungorus
Host-Specific Differences in Gut Microbiota Between Cricetulus barabensis and Phodopus sungorus
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DOI：
10.1007/s00284-023-03274-4
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发表时间：
2023-05-01
影响因子：
2.6
通讯作者：
Xu，Laixiang
中科院分区：
文献类型：
--
作者：
Fan，Chao;Xue，Huiliang;Xu，Laixiang
肠道菌群在宿主的健康中起着重要作用，通常与动物的生理过程有关。宿主特异性因素和环境因素都参与了肠道微生物群落的形成，有必要确定宿主主导的动物物种肠道微生物群的差异，以更好地解释它们如何影响宿主生活史策略的选择。在这里，条纹仓鼠Cricetulus barabensis和Djungarian hamstersPhotopus sungorus在相同的控制条件下饲养，并收集粪便样品以比较肠道微生物群。在条纹仓鼠中观察到的Shannon指数高于Djungarian仓鼠。效应量的线性判别分析表明，富集的家庭毛螺菌科和generaMuribaculum和Oscillillillitrium条纹仓鼠，家庭丹毒和genusTuricillitrium在Djungarian仓鼠富集。在前10个扩增子序列变体（ASV）中，8个在两种仓鼠物种之间显示出显著不同的相对丰度。黑线仓鼠共现网络中的正相关性和平均度均小于准噶尔仓鼠，表明肠道细菌间协同作用的复杂性不同。采用中性群落模型拟合，黑线仓鼠肠道微生物群落的R2值高于准噶尔仓鼠。这些差异与两种仓鼠生活方式的变化有一定程度的一致性。这项研究为了解肠道微生物群及其与啮齿动物宿主的联系提供了见解。
Gut microbiota plays an important role in the health of the host and is usually associated with the physiological processes of animals. Both host-specific factors and environmental factors are involved in the shaping of the gut microbial community, and it is necessary to identify the host-dominated differences in gut microbiota among animal species to better explain how they affect the choice of life history strategies in hosts. Here, striped hamstersCricetulus barabensisand Djungarian hamstersPhodopus sungoruswere housed under the same controlled conditions, and fecal samples were collected to compare gut microbiota. A higher Shannon index was observed in striped hamsters than in Djungarian hamsters. Linear discriminant analysis of effect size showed enrichment of the family Lachnospiraceae and generaMuribaculumandOscillibacterin striped hamsters, with the enrichment of family Erysipelotrichaceae and genusTuricibacterin Djungarian hamsters. Among the top 10 amplicon sequence variants (ASVs), eight showed significantly different relative abundance between the two hamster species. The positive correlations and average degree in the co-occurrence network of striped hamsters were less than those of Djungarian hamsters, showing different complexity of synergistic effects among the gut bacteria. The gut microbial community of striped hamsters had a higherR2value than that of Djungarian hamsters when fitted with a neutral community model. These differences have a degree of consistency with the variation in the lifestyles of the two hamster species. The study provides insights into the understanding of gut microbiota and its connections with rodent hosts.