Measurement of HbA1c Concentration Using Photoacoustic Spectroscopy*
Measurement of HbA1c Concentration Using Photoacoustic Spectroscopy*
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使用光声光谱测量 HbA1c 浓度*
DOI：
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发表时间：
2011
期刊：
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通讯作者：
J. Matsuda
中科院分区：
文献类型：
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作者：
N. Wadamori;J. Matsuda
研究了基于光声光谱技术进行HbA1c浓度无创测量的可行性。新开发了球体型信号检测池，提高了检测池的灵敏度。该单元经过适当设计，使得单元的两个焦点的位置分别对应于皮肤下的检测麦克风和光声源的位置。该电池能够将 Q 值提高到传统亥姆霍兹型电池的八倍。整个系统的信噪比提高到48 dB，足以检测深层皮肤层产生的光声信号。通过使用由猪皮肤组织和 HbA1c 溶液组成的模型进行 HbA1c 浓度测量实验来评估所开发系统的性能。在实验中，使用双波长光谱法根据光声信号确定 HbA1c 浓度。结果表明，我们的光声系统测量的 HbA1c 浓度的准确度为 3%。
The feasibility of being able to conduct non-invasive measurement of HbA1c concentration based on photoacoustic spectroscopy was studied. A spheroid-type signal-detecting cell was newly developed to improve the sensitivity of the detecting cell. The cell was appropriately designed so that the positions of two focal points of the cell corresponded to those of a detecting microphone and a photoacoustic source under the skin, respectively. This cell was able to improve the Q-value eightfold that of a conventional Helmholtz-type cell. The signal-to-noise ratio of the total system was improved to 48 dB, which may be sufficient to detect the photoacoustic signal generated from a deep skin layer. The performance of the system developed was evaluated by conducting measurement experiments on HbA1c concentration using a phantom that consisted of a swine skin tissue and an HbA1c solution. In the experiments, the concentration of HbA1c was determined from photoacoustic signals using dual-wavelength spectroscopy. It was shown that the HbA1c concentration was measured by our photoacoustic system with an accuracy of 3%.