REPRODUCTIVE DYSFUNCTION IN RHESUS-MONKEYS EXPOSED TO LOW-LEVELS OF POLYCHLORINATED BIPHENYLS (AROCLOR 1248)
REPRODUCTIVE DYSFUNCTION IN RHESUS-MONKEYS EXPOSED TO LOW-LEVELS OF POLYCHLORINATED BIPHENYLS (AROCLOR 1248)
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DOI：
10.1016/s0015-6264(76)80251-9
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发表时间：
1976-01-01
期刊：
影响因子：
--
通讯作者：
ALLEN, JR
中科院分区：
文献类型：
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作者：
BARSOTTI, DA;MARLAR, RJ;ALLEN, JR
向18只雌性和4只雄性成年恒河猴喂食多氯联苯（PCB）Aroclor 1248，饲料中的多氯联苯（PCB）含量为2.5或5.0 ppm。这些水平等于某些供人类食用的食品中允许的浓度的50%。在食用这些饮食2个月后，一些雌性动物出现痤疮、脱发、红斑和眼睑肿胀，到6个月时。所有雌性动物都表现出一定程度的这些变化。血脂的变化逐渐发展，有低胆固醇血症、低血脂症和血清甘油三酯降低的趋势。此外，血浆白蛋白/球蛋白比值发生变化，血清谷氨酰胺转氨酶活性升高。对皮下脂肪的分析表明，多氯联苯异构体在脂肪组织中积累。该组织中的浓度达到平台期，之后仅观察到轻微变化。在4个月内，月经周期改变;月经增多和月经过多频繁发生，有时闭经明显。动物维持妊娠的能力受损，如频繁吸收和流产所示。当婴儿出生时，他们是小的，多氯联苯的经胎盘运动是显而易见的，从新生儿的皮肤活检和尸检组织1死产的分析。此外，在母乳喂养期间，婴儿体内多氯联苯的积累也会增加。14个月后，所有喂食5.0 ppm PCB的雄性动物仅表现出轻微的眶周水肿和红斑。在饮食和显示没有改变他们的繁殖能力。所提供的数据表明，雌性非人灵长类动物长期、低水平接触多氯联苯会影响许多重要的生物参数。
Eighteen female and 4 male adult rhesus monkeys were fed the polychlorinated biphenyl (PCB) Aroclor 1248 at levels of either 2.5 or 5.0 ppm in the diet. These levels are equal to, and 50% of, the concentration allowed in certain foods destined for human consumption. After consuming these diets for 2 mo., some of the females developed acne, alopecia, erythema and swelling of the eyelids, and by 6 mo. all females exhibited these changes to some degree. Modifications in serum lipids developed gradually, with a trend towards hypocholesterolemia, hypolipidemia and decreased serum triglycerides. In addition there was a shift in the plasma albumin/globulin ratio and an increase in serum glutamic-pyruvic transaminase activity. Analysis of subcutaneous fat showed an accumulation of the PCB isomers in the adipose tissue. The concentrations in this tissue reached a plateau, after which only slight variations were observed. Within 4 mo., menstrual cycles were altered; menostaxis and menorrhagia occurred frequently and at times amenorrhea was apparent. The ability of the animals to maintain pregnancy was impaired, as indicated by frequent resorptions and abortions. When infants were born they were small, and the transplacental movement of PCBs was evident from analyses of skin biopsies of neonates and of autopsy tissue from 1 stillborn. Moreover, additional accumulation of PCBs occurred in infants during breast feeding. All males fed 5.0 ppm PCB exhibited only slight periorbital edema and erythema after 14 mo. on the diet and showed no alterations in their breeding capacities. The data presented indicate that long-term, low-level exposure of female non-human primates to PCBs can affect many important biological parameters.