Influence of the conjoint administration of insulin and glucagon upon hepatic regeneration.
Influence of the conjoint administration of insulin and glucagon upon hepatic regeneration.
复制标题
胰岛素和胰高血糖素联合给药对肝再生的影响。
DOI：
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发表时间：
1986
期刊：
影响因子：
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通讯作者：
J. Balibrea
中科院分区：
文献类型：
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作者：
J. D. de Diego;L. M. Molina;J. Buján;P. Simón;M. Géa;A. Menchero;J. Balibrea
在未去内脏的大鼠上，以氚胸苷掺入核脱氧核糖核酸为参数，证实了联合应用胰岛素和胰升糖素对70%肝切除后再生反应的影响。对于没有激素刺激和仅用胰高血糖素刺激的动物，这种反应更早、更强烈(我们之前报道过)。这种反应在非实质细胞和肝细胞中都相对较大，特别是在肝细胞中，后者是门静脉周围区胸腺嘧啶核苷掺入早期峰值的主要原因，表明再生活性高于中间小叶区和中心小叶区。在我们看来，这表明了某些肝外体液因子在再生过程中的重要性。因此，我们的研究结果确定了胰腺激素--胰岛素和胰升糖素--在肝脏再生中的决定作用和协同作用。
In noneviscerated rats, the influence of the conjoint administration of insulin and glucagon in the regenerative response triggered by 70 per cent hepatectomy using the incorporation of tritiated thymidine by nuclear deoxyribonucleic acid as a parameter has been demonstrated. The response was earlier and more intense in relation to animals not hormonally stimulated and stimulated only with glucagon (previously reported by us). Such a response has been comparatively greater both in the nonparenchymal cells and in the hepatocytes, especially in the latter, which are the main cause of the early peak of thymidine incorporation in the periportal zones indicating a greater regenerative activity than in the intermediate and centrolobular zones. In our opinion, this indicates the importance of certain extrahepatic humoral agents in the manifestation of the regenerative process. Therefore, the results of our study ascertain the determining role and synergistic action of the pancreatic hormones--insulin and glucagon--in hepatic regeneration.