High prevalence of vitamin D deficiency in pregnant non-Western women in The Hague, Netherlands.
High prevalence of vitamin D deficiency in pregnant non-Western women in The Hague, Netherlands.
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DOI：
10.1093/ajcn/84.1.350
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发表时间：
2006-08
期刊：
影响因子：
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通讯作者：
I. M. van der Meer;N. S. Karamali;A. Boeke;P. Lips;B. Middelkoop;I. Verhoeven;J. D. Wuister
中科院分区：
文献类型：
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作者：
I. M. van der Meer;N. S. Karamali;A. Boeke;P. Lips;B. Middelkoop;I. Verhoeven;J. D. Wuister
维生素D缺乏症在生活在北方国家的深色皮肤人群中很常见。怀孕期间缺乏维生素D可能会对母亲和孩子造成严重后果。目的：目的是确定居住在荷兰大城市海牙的几个种族背景的孕妇维生素D缺乏症的患病率。设计：大量非西方移民就诊的助产士将血清25-羟基维生素D [25(OH)D]的评估添加到妊娠第12周就诊妇女的标准血液检查中。随后，市卫生局从助产士的档案中（2002年6月至2004年3月）收集了更多数据：背景变量、使用烟草或酒精或药物以及传染病。这些妇女按种族分为西方人、土耳其人、摩洛哥人和其他非西方人。结果358名产妇在助产士档案中发现维生素D浓度。在这些女性中，29%是西方人，22%是土耳其人，19%是摩洛哥人。土耳其妇女（15.2 +/- 12.1 nmol/L）、摩洛哥妇女（20.1 +/- 13.5 nmol/L）和其他非西方妇女（26.3 +/- 25.9 nmol/L）的平均血清25(OH)D浓度显著（P </= 0.001）低于西方妇女（52.7 +/- 21.6 nmol/L）。22%的土耳其妇女血清25(OH)D低于检出限。种族之间的差异没有被年龄、社会经济地位或性别平等等其他决定因素所混淆。结论荷兰非西方孕妇维生素D缺乏症患病率非常高，应推荐筛查。
BACKGROUND Vitamin D deficiency is common in dark-skinned persons living in northern countries. Vitamin D deficiency during pregnancy may have serious consequences for both mother and child. OBJECTIVE The objective was to ascertain the prevalence of vitamin D deficiency in pregnant women of several ethnic backgrounds who were living in The Hague, a large city in the Netherlands. DESIGN Midwives whose practice was visited by a large number of non-Western immigrants added the assessment of serum 25-hydroxyvitamin D [25(OH)D] to the standard blood test given to women who visited the practice during week 12 of pregnancy. Subsequently, the Municipal Health Service collected additional data from the midwives' files (June 2002 through March 2004): background variables, use of tobacco or alcohol or drugs, and infectious diseases. The women were grouped ethnically as Western, Turkish, Moroccan, and other non-Western. RESULTS The vitamin D concentrations of 358 women were found in the midwives' files. Of these women, 29% were Western, 22% were Turkish, and 19% were Moroccan. Mean serum 25(OH)D concentrations in Turkish (15.2 +/- 12.1 nmol/L), Moroccan (20.1 +/- 13.5 nmol/L), and other non-Western women (26.3 +/- 25.9 nmol/L) were significantly (P </= 0.001) lower than those in Western women (52.7 +/- 21.6 nmol/L). Serum 25(OH)D was below the detection limit in 22% of the Turkish women. The differences between ethnic groups were not confounded by other determinants such as age, socioeconomic status, or parity. CONCLUSIONS The prevalence of vitamin D deficiency in pregnant non-Western women in the Netherlands is very high, and screening should be recommended.