Monte Carlo prediction of near-infrared light propagation in realistic adult and neonatal head models
Monte Carlo prediction of near-infrared light propagation in realistic adult and neonatal head models
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DOI：
10.1364/ao.42.002881
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发表时间：
2003-06-01
期刊：
影响因子：
1.9
通讯作者：
Okada, E
中科院分区：
文献类型：
--
作者：
Fukui, Y;Ajichi, Y;Okada, E
在近红外光谱和成像中，检测到的信号对大脑激活的灵敏度和询问的组织的体积在临床上是重要的。光在成人和新生儿头部的传播受到低散射脑脊液层的存在的强烈影响。头部的异质结构对光在成人脑中传播的影响很可能不同于新生儿脑中的影响，因为新生儿头部的表层组织的厚度和脑的光学性质与成人头部的相当不同。在这项研究中，光传播的二维现实的成人和新生儿头部模型，其几何形状产生的磁共振成像扫描的人的头部，预测通过蒙特卡罗模拟。三明治结构是高散射头骨和灰质之间的低散射脑脊液层，强烈影响成人头部大脑中的光传播。灰质中吸收变化的灵敏度得到提高，但是，强敏感区域仅限于灰质的浅区域。新生儿大脑的高吸收对头部中的光传播产生类似的影响。新生儿大脑中的强敏感区域仅限于灰质;然而，空间敏感度分布穿透到白色物质的更深区域（C）2003年美国光学学会。
In near-infrared spectroscopy and imaging, the sensitivity of the detected signal to brain activation and the volume of interrogated tissue are clinically important. Light propagation in adult and neonatal heads is strongly affected by the presence of a low-scattering cerebrospinal fluid layer. The effect of the heterogeneous structure of the head on light propagation in the adult brain is likely to be different from that in the neonatal brain because the thickness of the superficial tissues and the optical properties of the brain of the neonatal head are quite different from those of the adult head. In this study, light propagation in the two-dimensional realistic adult and neonatal head models, whose geometries are generated from a magnetic resonance imaging scan of the human heads, is predicted by Monte Carlo simulation. The sandwich structure, which is a low-scattering cerebrospinal fluid layer held between the high-scattering skull and gray matter, strongly affects light propagation in the brain of the adult head. The sensitivity of the absorption change in the gray matter is improved; however, the intensely sensitive region is confined to the shallow region of the gray matter. The high absorption of the neonatal brain causes a similar effect on light propagation in the head. The intensely sensitive region in the neonatal brain is confined to the gray matter; however, the spatial sensitivity profile penetrates into the deeper region of the white matter (C) 2003 Optical Society of America.