Social isolation stress down-regulates cortical early growth response 1 (Egr-1) expression in mice
Social isolation stress down-regulates cortical early growth response 1 (Egr-1) expression in mice
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DOI：
10.1016/j.neures.2012.04.004
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发表时间：
2012-07-01
影响因子：
2.9
通讯作者：
Murakami, Yukihisa
中科院分区：
文献类型：
--
作者：
Matsumoto, Kinzo;Ono, Kazuya;Murakami, Yukihisa
社会隔离应激诱导行为障碍，如攻击性，认知障碍，和缺陷的前脉冲抑制小鼠。因此，社会隔离小鼠被研究为神经精神疾病如精神分裂症的动物模型。最近，早期生长反应（Egr）基因表达水平的下降，在精神分裂症患者死后的大脑报告。本研究探讨了社会隔离应激对额叶皮层Egr mRNA和蛋白表达水平的影响。社交隔离应激显著下调了皮层神经元核团Egr-1蛋白和Egr-1基因转录本的表达，其下调程度依赖于社交隔离时间。这种应激对纹状体中Egr-1的表达水平或额叶皮层中其他Egr家族成员（Egr-2、-3和-4）的表达水平没有影响。这些结果表明，Egr-1在额叶皮层表达的减少可能参与了社会隔离应激诱导的行为异常。(C)2012 Elsevier爱尔兰有限公司和日本神经科学学会。All rights reserved.
Social isolation stress induces behavioral disturbances such as aggression, cognitive impairments, and deficits in prepulse inhibition in mice. Social isolation mice have, therefore, been studied as an animal model of neuropsychiatric disorders such as schizophrenia. Recently, the decrease in early growth response (Egr) gene expression levels were reported in the post-mortem brains of schizophrenia patients. In this study, we investigate the effects of social isolation stress on the expression levels of Egr mRNA and protein in the frontal cortex. Social isolation stress exposure significantly down-regulated the expression of Egr-1 protein and Egr-1 gene transcript in nucleus of cortical neurons in a manner dependent on a social isolation period. This stress had no effect on the expression level of Egr-1 in the striatum or the expression levels of other Egr family members (Egr-2, -3, and -4) in the frontal cortex. These results suggest that the decrease in Egr-1 expression in the frontal cortex may be involved in social isolation stress-induced behavioral abnormalities. (C) 2012 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.