Voice coil based endomicroscopic optical coherence tomography probe for in vivo mucosa examination
Voice coil based endomicroscopic optical coherence tomography probe for in vivo mucosa examination
复制标题
用于体内粘膜检查的基于音圈的显微光学相干断层扫描探头
DOI：
10.1117/12.2578787
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Schulz-Hildebrandt H
中科院分区：
文献类型：
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作者：
Ahrens M;Idel C;König P;Hüttmann G;Schulz-Hildebrandt H
我们提出了一种基于音圈致动器的内窥镜OCT探头，用于鼻粘膜的体内检查。 侧视内窥镜的头端直径为3 mm，可用长度为7 cm。梯度折射率（GRIN）透镜光学器件实现3 µ m的横向分辨率。在40 Hz和100 Hz之间的致动器频率下，扫描范围高达2 mm。基于超连续谱激光的mOCT系统在700 µ m的深度范围内实现1 µ m的轴向分辨率。 后处理包括正弦扫描模式的线性化和来自B扫描的时间序列的配准。 在离体小鼠气管上证明了新设计的潜力。基本的形态结构，如上皮细胞与纤毛细胞，腺体，血液和淋巴管，以及粘液运输可视化。
We present an endomicroscopic OCT probe for in vivo examination of the mucosa in the nose based on a voice coil actuator. The side-viewing endoscope has a tip diameter of 3 mm and a usable length of 7 cm. A graded-index (GRIN) lens optics achieve a lateral resolution of 3 µm. At an actuator frequency between 40 Hz and 100 Hz the scanning range is up to 2 mm. A supercontinuum laser based mOCT system enables an axial resolution of 1 µm at a depth range of 700 µm. The postprocessing includes the linearization of the sinusoidal scan pattern and a registration of the time series from B-scans. The potential of the new design was demonstrated on ex-vivo mouse trachea. Essential morphological structures such as epithelium with ciliated cells, glands, blood and lymph vessels and also mucus transport were be visualized.