Studies on suppressor cell function in thyroid diseases.
Studies on suppressor cell function in thyroid diseases.
复制标题
甲状腺疾病中抑制细胞功能的研究。
DOI：
--
复制
发表时间：
1979
影响因子：
5.8
通讯作者：
L. Degroot
中科院分区：
文献类型：
--
作者：
N. Aoki;K. Pinnamaneni;L. Degroot
对Graves病、桥本甲状腺炎和甲状腺癌患者以及健康受试者外周血单个核细胞的抑制细胞功能进行了检测。通过两种方法评估抑制细胞的功能：1)预培养24小时后增强的成纤维细胞生成；2)刀豆蛋白A诱导的抑制活性。这两项测试的结果是一致的，表明与健康对照组相比，Graves病患者的抑制细胞功能显着降低，但桥本甲状腺炎和甲状腺癌患者的抑制细胞功能没有变化。Graves病患者经抗甲状腺药物治疗后甲状腺功能恢复正常，但抑制细胞功能较未治疗患者有所改善(P=NS)。Graves病人群中抑制细胞功能的低活性可能是一种基于疾病人群特有的遗传异常的体质特征。
Suppressor cell function of peripheral mononuclear cells has been examined in patients with Graves' disease, Hashimoto's thyroiditis, and thyroid cancer, as well as in healthy subjects. Suppressor cell function was assessed through two methods: 1) measurement of enhanced blastogenesis after 24-h preculture and 2) concanavalin A-inducible suppressor activity. The results from the two tests were coincident and indicate that suppressor cell function was significantly decreased in the Graves' disease population but not changed in either the Hashimoto's thyroiditis or the thyroid cancer groups compared to healthy controls. The impairment of suppressor cell function in the Graves' disease population was still observed when patients became euthyroid by treatment with antithyroid drugs, although the treated patients had improved suppressor cell function compared to untreated patients (P = NS). Low activity of suppressor cell function in the Graves' disease population might be a constitutional character based on an inherited abnormality specific for the disease population.