Enhancing antiepileptic drug adherence: A randomized controlled trial
Enhancing antiepileptic drug adherence: A randomized controlled trial
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DOI：
10.1016/j.yebeh.2009.09.014
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发表时间：
2009-12-01
影响因子：
2.6
通讯作者：
Reuber, Markus
中科院分区：
文献类型：
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作者：
Brown, Ian;Sheeran, Paschal;Reuber, Markus
抗癫痫药物（AED）治疗的次优依从性是常见的，并增加癫痫持续状态和不明原因猝死的风险。这项随机对照试验旨在证明实施意向干预（包括完成一份简单的自我管理问卷，将服药意向与特定时间、地点和其他活动联系起来）是否可以改善AED治疗计划的依从性。在81例随机分配的癫痫患者中，69例完成了1个月的监测期，并对片剂服用进行了客观测量（药瓶打开的电子登记，药物事件监测系统[MEMS]）。与对照组相比，干预组参与者在所有三个结局方面的依从性均有所改善：总剂量（93.4% vs. 79.1%），服用正确剂量的天数（88.7% vs. 65.3%）和按计划服用剂量（78.8% vs. 55.3%）（P < 0.01）。实施意图干预可能是一种易于管理和有效的手段，促进AED的依从性。(C)2009 Elsevier Inc. All rights reserved.
Suboptimal adherence to antiepileptic drug (AED) treatment is commonplace, and increases the risk of status epilepticus and sudden unexplained death in epilepsy. This randomized controlled trial was designed to demonstrate whether an implementation intention intervention involving the completion of a simple self-administered questionnaire linking the intention of taking medication with a particular time, place, and other activity can improve AED treatment schedule adherence. Of the 81 patients with epilepsy who were randomized, 69 completed a 1-month monitoring period with an objective measure of tablet taking (electronic registration of pill bottle openings, Medication Event Monitoring System [MEMS]). Intervention participants showed improved adherence relative to controls on all three outcomes: doses taken in total (93.4% vs. 79.1%), days on which correct dose was taken (88.7% vs. 65.3%), and doses taken on schedule (78.8% vs. 55.3%) (P < 0.01). The implementation intention intervention may be an easy-to-administer and effective means of promoting AED adherence. (C) 2009 Elsevier Inc. All rights reserved.