Calcium-binding protein S100A4 in health and disease
Calcium-binding protein S100A4 in health and disease
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DOI：
10.1016/s0167-4889(98)00143-8
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发表时间：
1998-12-10
影响因子：
5.1
通讯作者：
Barraclough, R
中科院分区：
文献类型：
--
作者：
Barraclough, R
S100蛋白含有两个EF-手基序，并且通常具有未知的功能。其中一种蛋白质S100 A4是一种细胞内钙结合蛋白，存在于正常啮齿动物和人类细胞中。在培养的啮齿动物乳腺细胞中，S100 A4在一些转移性上皮细胞中的表达水平高于非转移性上皮细胞。类似地，在人类乳腺细胞系中，S100 A4在来自恶性肿瘤的培养细胞中的水平高于来自良性肿瘤的培养细胞。基因转移实验表明，啮齿动物或人S100 A4能够诱导转移能力，否则非转移性乳腺肿瘤细胞。此外，啮齿动物S100 A4转基因的表达可以诱导转基因模型系统中产生的良性肿瘤的转移。S100 A4的转移诱导作用的可能机制和人类癌症的相关性进行了讨论。(C)1998 Elsevier Science B. V.保留所有权利。
The S100 proteins contain two EF-hand motifs and are of generally unknown function. One of these proteins, S100A4, is an intracellular calcium-binding protein that is present in normal rodent and human cells. In cultured rodent mammary cells, S100A4 is expressed at a higher level in some metastatic epithelial cells than in non-metastatic counterparts. Similarly, in human breast cell lines, S100A4 is present at a higher level in cultured cells from the more malignant, than in those from the more benign rumours. Gene transfer experiments have shown that rodent or human S100A4 is able to induce metastatic capability in otherwise non-metastatic breast tumour cells. Furthermore, expression of rodent S100A4 transgenes can induce metastasis of benign tumours arising in transgenic model systems. Possible mechanisms for the metastasis-inducing effect of S100A4 and the relevance of these observations to human cancer are discussed. (C) 1998 Elsevier Science B.V. All rights reserved.