Adult neuronal regeneration induced by transgenic integrin expression
Adult neuronal regeneration induced by transgenic integrin expression
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DOI：
10.1523/jneurosci.21-13-04782.2001
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发表时间：
2001-07-01
影响因子：
5.3
通讯作者：
Condic, ML
中科院分区：
文献类型：
--
作者：
Condic, ML
在各种成人中枢神经系统损伤模型中，与成人神经元相比，胚胎神经元表现出优越的再生性能。目前尚不清楚年轻神经元如何在受伤的成年大脑中延伸轴突，而成年神经元无法再生。这项研究表明，培养的成体神经元不适应受损成体中枢神经系统的特征条件：低水平的生长促进分子和抑制性蛋白聚糖的存在。相反，年轻的神经元很容易适应这些相同的条件，并且适应伴随着生长促进分子受体（整合素家族的受体）表达的增加。令人惊讶的是，通过基因转移介导的单个α-整合素的表达，成年神经元的再生性能可以恢复到年轻神经元的再生性能。
In a variety of adult CNS injury models, embryonic neurons exhibit superior regenerative performance when compared with adult neurons. It is unknown how young neurons extend axons in the injured adult brain, in which adult neurons fail to regenerate. This study shows that cultured adult neurons do not adapt to conditions that are characteristic of the injured adult CNS: low levels of growth-promoting molecules and the presence of inhibitory proteoglycans. In contrast, young neurons readily adapt to these same conditions, and adaptation is accompanied by an increase in the expression of receptors for growth-promoting molecules (receptors of the integrin family). Surprisingly, the regenerative performance of adult neurons can be restored to that of young neurons by gene transfer-mediated expression of a single alpha -integrin.