T2 relaxation time analysis in patients with multiple sclerosis: correlation with magnetization transfer ratio
T2 relaxation time analysis in patients with multiple sclerosis: correlation with magnetization transfer ratio
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DOI：
10.1007/s00330-003-1946-0
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发表时间：
2004-01-01
影响因子：
5.9
通讯作者：
Gourtsoyiannis, N
中科院分区：
文献类型：
--
作者：
Papanikolaou, N;Papadaki, E;Gourtsoyiannis, N
本研究的目的是对多发性硬化症 (MS) 患者进行 T2 弛豫时间测量，并将其与磁化传输比 (MTR) 测量相关联，以便更详细地研究病变和正常白质 (NAWM) 中发生的各种组织病理学变化。对 13 名 MS 患者和 10 名年龄匹配的健康志愿者进行了总共 291 次 MTR 和 T2 弛豫时间测量。测量涉及多发性硬化症斑块 (105)、NAWM (80) 和“脏”白质 (DWM; 30)，在多发性硬化症患者中平均分配，而在健康志愿者中则平均分配正常白质 (NWM; 76)。进行了双指数 T2 弛豫时间分析，并且在所有亚组中使用线性回归分析评估了 MTR 和平均 T2 弛豫时间之间可能的线性关系。双指数松弛在“黑洞”病变（16.6%）和均匀增强斑块（10%）中更为明显，而 DWM、NAWM 和轻度低强度病变则呈现双指数行为，频率较低（分别为 6.6%、5% 和 3.1%）。非增强等信号病变和正常白质未显示任何双指数行为。单指数 T2 弛豫时间和 MTR 测量之间的线性回归分析表明 DWM 具有良好的相关性（r=-0.78，p
The aim of the current study was to perform T2 relaxation time measurements in multiple sclerosis (MS) patients and correlate them with magnetization transfer ratio (MTR) measurements, in order to investigate in more detail the various histopathological changes that occur in lesions and normal-appearing white matter (NAWM). A total number of 291 measurements of MTR and T2 relaxation times were performed in 13 MS patients and 10 age-matched healthy volunteers. Measurements concerned MS plaques (105), NAWM (80), and "dirty" white matter (DWM; 30), evenly divided between the MS patients, and normal white matter (NWM; 76) in the healthy volunteers. Biexponential T2 relaxation-time analysis was performed, and also possible linearity between MTR and mean T2 relaxation times was evaluated using linear regression analysis in all subgroups. Biexponential relaxation was more pronounced in "black-hole" lesions (16.6%) and homogeneous enhancing plaques (10%), whereas DWM, NAWM, and mildly hypointense lesions presented biexponential behavior with a lower frequency(6.6, 5, and 3.1%, respectively). Non-enhancing isointense lesions and normal white matter did not reveal any biexponentional behavior. Linear regression analysis between monoexponential T2 relaxation time and MTR measurements demonstrated excellent correlation for DWM(r=-0.78, p