Palladium-Catalyzed Hydrophosphination of Terminal Alkynes with Diphenylphosphine Oxide in the Presence of Tetraphenyldiphosphine Monoxide
Palladium-Catalyzed Hydrophosphination of Terminal Alkynes with Diphenylphosphine Oxide in the Presence of Tetraphenyldiphosphine Monoxide
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DOI：
10.1021/acs.organomet.2c00659
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发表时间：
2023-03-07
期刊：
影响因子：
2.8
通讯作者：
Ogawa，Akiya
中科院分区：
文献类型：
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作者：
Yamamoto，Yuki;Fujiwara，Kohsuke;Ogawa，Akiya
本研究以Pd(OAc)_2为催化剂，以具有P-P键的双膦化合物为催化剂，对Pd(OAc)_2催化的末端炔烃的氢磷化反应进行了详细的研究，并以Ph2P(O)H为磷源和氢源，成功地开发了一种新型的Pd(OAc)_2催化的末端炔烃的氢磷化反应。在Ph_2P(O)-PPh_2的催化作用下，成功地促进了这一转化，并以中等到高的产率得到了相应的烯基氧膦，并且具有很好的产物选择性。
In this study, the Pd(OAc)2-catalyzed hydrophosphination of terminal alkynes was investigated in detail by using various diphosphines, which have a P–P bond, and the detailed mechanistic insights led to the successful development of a novel Pd-catalyzed hydrophosphination of terminal alkynes using Ph2P(O)H as both the phosphorus and hydrogen source. This catalytic transformation was successfully promoted in the presence of catalytic Ph2P(O)–PPh2, and the corresponding alkenylphosphine oxide was obtained in moderate to excellent yields with excellent product selectivity.