Age and Gender Specific Thyroid Hormones and Their Relationships with Body Mass Index in a Large Chinese Population
Age and Gender Specific Thyroid Hormones and Their Relationships with Body Mass Index in a Large Chinese Population
复制标题
中国大量人群中年龄和性别特异性甲状腺激素及其与体重指数的关系
DOI：
10.5812/ijem.66450
复制
发表时间：
2019-01-01
影响因子：
2.1
通讯作者：
Cui, Bin
中科院分区：
文献类型：
--
作者：
Song, Qianqian;Chen, Xinxin;Cui, Bin
目的 研究大量中国人群中促甲状腺激素 (TSH)、游离三碘甲状腺原氨酸 (FT3) 和游离甲状腺素 (FT4) 与体重指数 (BMI) 的关系以及年龄和性别对这些关系的影响。方法选取某健康体检中心97997人作为研究对象。 TSH、FT3 和 FT4 的中位数（第 25 位和第 75 位）用于探讨基于性别、10 岁年龄组和 BMI 的趋势。通过广义加性模型（GAM）评估 TSH、FT3 和 FT4 与 BMI 的关系，并调整年龄和性别的影响。结果 应用我们的排除标准后，对 77,991 名甲状腺功能正常的参与者（45,428 名男性和 32,563 名女性）进行了分析。各年龄组中女性受试者的TSH水平中位数均显着高于男性（P < 0.05），而女性受试者中FT3水平中位数较低；然而，男性和女性受试者的中位 FT4 水平没有显着差异。 GAM分析显示TSH和FT3与BMI呈非线性正相关，并且这些关系明显受到年龄和性别的影响。然而，FT4与BMI呈负相关，年龄和性别的影响可忽略不计。结论 TSH、FT3、BMI经年龄和性别调整后呈非线性正二次关系。然而，FT4 与 BMI 呈负非线性关系，年龄和性别的影响可忽略不计。
Objectives To investigate the associations of thyroid-stimulating hormone (TSH), free triiodothyronine (FT3) and free thyroxine (FT4) with body mass index (BMI) and the effect of age and gender on these relationships in a large Chinese population. Methods A total of 97,997 individuals from a health examination center were selected. The medians (25th and 75th) of TSH, FT3 and FT4 were used to explore the trends based on gender, 10-year age groups and BMI. The relationships of TSH, FT3 and FT4 with BMI were assessed by generalized additive models (GAM) along with adjusting the effect of age and gender. Results After applying our exclusion criteria, 77,991 euthyroid participants (45,428 males and 32,563 females) were analyzed. The medians of TSH level based on BMI groups were significantly higher in female participants than those in males in all age groups (P < 0.05), and the median FT3 level was lower in female subjects; however, there was no significant difference between male and female subjects in median FT4 level. The GAM analysis showed the non-linear positive association of TSH and FT3 with BMI, and these relationships were markedly influenced by age and gender. However, FT4 had a negative relationship with BMI, with neglectable effect of age and gender. Conclusions TSH, FT3 and BMI have a non-linear and positive quadratic relationship after age and gender adjustment. FT4, however, has a negative non-linear relationship with BMI with neglectable influence of age and gender.