Gastric Bypass Surgery Attenuates Ethanol Consumption in Ethanol-Preferring Rats
Gastric Bypass Surgery Attenuates Ethanol Consumption in Ethanol-Preferring Rats
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DOI：
10.1016/j.biopsych.2012.01.035
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发表时间：
2012-09-01
影响因子：
10.6
通讯作者：
Benoit, Stephen C.
中科院分区：
文献类型：
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作者：
Davis, Jon F.;Schurdak, Jennifer D.;Benoit, Stephen C.
背景：Roux-en-Y胃旁路术（RYGB）是治疗肥胖及其相关并发症的有效减肥策略。重要的是，据报道RYGB程序可以减弱奖励相关的消费行为。目前的工作研究的假设，RYGB手术减弱乙醇的摄入量和奖励的背景下，频繁的乙醇consumption.Methods：要做到这一点，自我报告的乙醇摄入量进行了检查，在人类肥胖患者（n = 6165）之前和之后的RYGB程序。此外，我们利用RYGB的啮齿动物模型，并研究乙醇消耗和乙醇奖励的男性乙醇偏好（P）大鼠，这是有选择地培育消耗大量的乙醇。结果：患者报告，经常消耗的乙醇RYGB前报告减少消费RYGB手术后。此外，RYGB程序减少乙醇的摄入量和乙醇的增强性能在P大鼠。值得注意的是，RYGB手术对乙醇消耗的减弱作用与乙醇诱导的肠道激素胰高血糖素样肽-1（GLP-1）的增加有关。GLP-1激动剂的药理学给药减弱了假手术P大鼠的乙醇消耗。此外，药物替代的肠道激素生长激素释放肽恢复饮酒行为P大鼠以下RYGB.Conclusions：总的来说，这些研究结果揭示了潜在的RYGB手术，以减少乙醇消耗在一些人和大鼠。此外，我们的数据表明，这种调节部分是通过减少奖励来实现的，并通过肠道激素GLP-1和ghrelin进行修改。
Background: Roux-en-Y gastric bypass (RYGB) surgery is an effective weight loss strategy employed to treat obesity and associated complications. Importantly, the RYGB procedure has been reported to attenuate reward-related consummatory behaviors. The present work examined the hypothesis that RYGB surgery attenuates ethanol intake and reward in the context of frequent ethanol consumption.Methods: To do this, self-report of ethanol intake was examined in human bariatric patients (n = 6165) before and following the RYGB procedure. In addition, we utilized a rodent model of RYGB and examined ethanol consumption and ethanol reward in male ethanol-preferring (P) rats, which are selectively bred to consume large volumes of ethanol.Results: Patients that reported frequent consumption of ethanol before RYGB reported decreased consumption following RYGB surgery. Moreover, the RYGB procedure decreased ethanol intake and the reinforcing properties of ethanol in P rats. Notably, the attenuating effect of RYGB surgery on ethanol consumption was associated with ethanol-induced increases in the gut hormone glucagon-like peptide-1 (GLP-1). Pharmacologic administration of GLP-1 agonists attenuated ethanol consumption in sham P rats. In addition, pharmacologic replacement of the gut hormone ghrelin restored drinking behavior in P rats following RYGB.Conclusions: Collectively, these findings unveil the potential of RYGB surgery to attenuate ethanol consumption in some humans and rats. Furthermore, our data indicate that this regulation is achieved, in part, through reduction of reward and is modified by the gut hormones GLP-1 and ghrelin.