Electrical Coupling Mediates Tunable Low-Frequency Oscillations and Resonance in the Cerebellar Golgi Cell Network
Electrical Coupling Mediates Tunable Low-Frequency Oscillations and Resonance in the Cerebellar Golgi Cell Network
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DOI：
10.1016/j.neuron.2008.11.028
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发表时间：
2009-01-15
期刊：
影响因子：
16.2
通讯作者：
Dieudonne, Stephane
中科院分区：
文献类型：
--
作者：
Dugue, Guillaume P.;Brunel, Nicolas;Dieudonne, Stephane
强直性运动控制涉及整个感觉运动系统（包括小脑区域）的低频（5-30 Hz）活动的振荡同步。我们研究了小脑振荡的机制。我们发现，高尔基中间神经元，门在小脑皮层输入层的信息传递，广泛耦合通过电突触。在体外去极化时，这些神经元表现出低频振荡同步，对颗粒细胞施加节律性抑制。结合实验和建模，我们表明，电传输的尖峰后超极化是振荡的人口同步的重要组成部分。尽管有很强的异质性，有节奏的发射出现，是频率调谐的平均兴奋性输入到高尔基体细胞，并显示明显的共振时，由振荡输入驱动的建模网络。在体内，单一的高尔基体细胞的活动被发现同步低频LFP振荡发生在安静的清醒。这些结果表明，在振荡的相互作用，高尔基体细胞在协调小脑感觉运动整合的主要作用。
Tonic motor control involves oscillatory synchronization of activity at low frequency (5-30 Hz) throughout the sensorimotor system, including cerebellar areas. We investigated the mechanisms underpinning cerebellar oscillations. We found that Golgi interneurons, which gate information transfer in the cerebellar cortex input layer, are extensively coupled through electrical synapses. When depolarized in vitro, these neurons displayed low-frequency oscillatory synchronization, imposing rhythmic inhibition onto granule cells. Combining experiments and modeling, we show that electrical transmission of the spike afterhyperpolarization is the essential component for oscillatory population synchronization. Rhythmic firing arises in spite of strong heterogeneities, is frequency tuned by the mean excitatory input to Golgi cells, and displays pronounced resonance when the modeled network is driven by oscillating inputs. In vivo, unitary Golgi cell activity was found to synchronize with low-frequency LFP oscillations occurring during quiet waking. These results suggest a major role for Golgi cells in coordinating cerebellar sensorimotor integration during oscillatory interactions.